Results 101 to 110 of about 4,622,579 (388)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Anatomic Knowledge and Perceptions of the Adequacy of Anatomic Education Among Applicants to Orthopaedic Residency. [PDF]

, 2017
BackgroundThe time dedicated to the study of human anatomy within medical school curriculums has been substantially reduced. The effect of this on the knowledge of incoming orthopaedic trainees is unknown.
Acosta, Anna, Dawson, Jack, Firoozabadi, Reza, Lee, Nicolas, Nussenbaum, Fernando, Perkins, Christopher, Shaw, Jeremy, Toogood, Paul   +7 more
core  

Virtual reality training and assessment in laparoscopic rectum surgery [PDF]

, 2015
Background: Virtual-reality (VR) based simulation techniques offer an efficient and low cost alternative to conventional surgery training. This article describes a VR training and assessment system in laparoscopic rectum surgery.
Aggarwal, Alastrué, Ali, Antman, Atkinson, Basdogan, Bathe, Chang, Chang, Chang, Chih-Hao, Choi, Chuong, Cotin, Francone, Ganovelli, Grantcharov, Gurusamy, Heng, Hong, Hájek, Lin, Lu, Maciel, Mollemans, Pan, Pan, Picinbono, Prime, Wu, Zhao   +30 more
core   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Functional radical cervical dissection for differentiated thyroid cancer: the experience of a single center [PDF]

, 2018
There is ongoing debate regarding the role of neck dissection in differentiated thyroid cancer, about its usefulness in elective settings, and the increased costs regarding morbidity and operative time.
Adrian, Tulin, Alecu, Lucian, Cristian, Balalau, Hainarosie, Razvan, Jecan, Radu, Nitipir, Cornelia, Orlov, Cristina, Pantea Stoian, Anca, Pituru, Silviu, Poiana, Catalina, Slavu, Iulian, Tomescu, Luminita, Tulin, Raluca   +12 more
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Dissection of the ascending thoracic aorta as a complication of percutaneous coronary intervention

Vascular Health and Risk Management, 2008
Cihangir Uyan, Huseyin Arinc, Huseyin Gunduz, Ramazan AkdemirAbant izzet Baysal University, izzet Baysal Medical Faculty, Cardiology Department, 14280 Golkoy, Bolu, TurkeyAbstract: Acute aortic dissection is a medical emergency with high morbidity and ...
Cihangir Uyan, Huseyin Arinc, Huseyin Gunduz, Ramazan Akdemir   +3 more
doaj  

Spontaneous Coronary Artery Dissection: A Case Series of 9 Patients With Literature Review. [PDF]

, 2018
Spontaneous coronary artery dissection is an increasingly recognized nonatherosclerotic cause of acute coronary syndrome. Reports regarding the prognosis and natural history of this disease are limited.
Ali, Nouman Safdar, Anjum, Reema, Ghani, MD, Ali Raza, Hashmi, Arsalan Talib, Inayat, Faisal, Klugherz, Bruce D., Riaz, Iqra, Viray, Michael, Virk, Hafeez Ul Hassan   +8 more
core   +2 more sources

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source