Results 51 to 60 of about 1,714,800 (332)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Knowledge acquisition and dissemination for emergency situation [PDF]

open access: yes, 2005
Emergency situation is highly uncertain, dynamic, time pressure in making decisions and involves multi organizations and multi jurisdiction level.
Ku-Mahamud, Ku Ruhana   +1 more
core  

Highly intensive data dissemination in complex networks

open access: yes, 2016
This paper presents a study on data dissemination in unstructured Peer-to-Peer (P2P) network overlays. The absence of a structure in unstructured overlays eases the network management, at the cost of non-optimal mechanisms to spread messages in the ...
D'Angelo, Gabriele, Ferretti, Stefano
core   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis

open access: yesHealth Technology Assessment, 2020
Background: Early intensive applied behaviour analysis-based interventions are intensive interventions for autistic children that are often delivered on a one-to-one basis for 20–50 hours per week.
Mark Rodgers   +9 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

Data visualisation in scoping reviews and evidence maps on health topics: a cross-sectional analysis

open access: yesSystematic Reviews, 2023
Background Scoping reviews and evidence maps are forms of evidence synthesis that aim to map the available literature on a topic and are well-suited to visual presentation of results.
Emily South, Mark Rodgers
doaj   +1 more source

The Database of Abstracts of Reviews of Effects (DARE) [PDF]

open access: yes, 2002
Systematic reviews are useful tools for busy decision-makers because they identify, appraise and synthesise the available research evidence on a particular topic. Many thousands of systematic reviews relevant to health care have been published.
Centre for Reviews and Dissemination, University of York
core  

Dissimilarity metric based on local neighboring information and genetic programming for data dissemination in vehicular ad hoc networks (VANETs) [PDF]

open access: yes, 2018
This paper presents a novel dissimilarity metric based on local neighboring information and a genetic programming approach for efficient data dissemination in Vehicular Ad Hoc Networks (VANETs). The primary aim of the dissimilarity metric is to replace
Gutiérrez Reina, Daniel   +3 more
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

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