Results 131 to 140 of about 2,385 (288)

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

open access: yesAdvanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang   +20 more
wiley   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

open access: yesAdvanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu   +18 more
wiley   +1 more source

Intégration régionale et crise sécuritaire: regard sur l’adhésion de la RDC à la Communauté des États de l’Afrique de l’Est [PDF]

open access: yesMouvements et Enjeux Sociaux
Pour faire face à la dynamique de la mondialisation, les Etats africains avaient levé l’option de s’organiser en différentes communautés économiques régionales en vue d’atténuer les chocs économiques exogènes.
Jérôme MUNGUKENDE PITHUA
doaj  

An analysis of how health systems integrated priority-setting in the pandemic planning in a sample of Latin America and the Caribbean countries. [PDF]

open access: yesHealth Res Policy Syst, 2022
Vélez CM   +6 more
europepmc   +1 more source

Bistable Networks Enable Complex Shape Changes

open access: yesAdvanced Science, EarlyView.
Transition‐controlled metamaterials are networks of bistable mechanical memory that store local binary states and express them as global shape change. By decoupling low‐force programming from high‐force holding, a single lattice is reconfigured into distinct 2D profiles and 3D surfaces without continuous actuation, enabling reusable morphing materials ...
Sawyer Thomas, Jeffrey Lipton
wiley   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin   +17 more
wiley   +1 more source

Editorial. [PDF]

open access: yesNotes Rec R Soc Lond, 2017
Marsden B.
europepmc   +1 more source

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