Results 31 to 40 of about 54,418 (308)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Brave New World Meets Nineteen Eighty-four in a New Golden Age: On the Passing of Liu Xiaobo, Advent of Big Data, and Resurgence of China as World Power [PDF]

open access: yesContemporary Chinese Political Economy and Strategic Relations: An International Journal, 2018
This paper aims to discuss recent years’ worrying development in the intensified persecution of dissidents in the People’s Republic of China, as most vividly symbolised by the death of the country’s high-profile prisoner of conscience Liu Xiaobo, and the
Emile Kok-Kheng Yeoh
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Introduction – Political Governance and Strategic Relations: Domestic-Foreign Policy Nexus and China’s Rise in the Global System [PDF]

open access: yesContemporary Chinese Political Economy and Strategic Relations: An International Journal, 2016
Recent years have witnessed several momentous developments in the political economy of the People’s Republic of China (PRC) both on the domestic front and in her foreign relations.
Emile Kok-Kheng Yeoh
doaj  

Europa Środkowa – wspólnota tekstów. Intertekstualność jako przestrzeń funkcjonowania i podtrzymywania mitu środkowoeuropejskiego

open access: yesSprawy Narodowościowe. Seria nowa, 2016
Central Europe – a community of texts. Intertextuality as a  plane of functioning and maintaining the myth of Central Europe In this article I examine two primary (sets of) questions: 1.
Ilija Upalevski
doaj   +1 more source

Being an Activist:Feminist Citizenship Through Transformations of Yugoslav and Post-Yugoslav Citizenship Regimes [PDF]

open access: yes, 2013
The Yugoslav wars of succession have had a great impact on how feminism in the region has been researched and written about. A lot of significant research has addressed relation of feminism to (anti-) nationalism and peace-building processes, whereas the
Zaharijevic, Adriana
core   +4 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Discourse Beyond Borders: Periodicals, Dissidents, and European Cultural Spaces

open access: yesJournal of European Periodical Studies, 2018
Émigré periodicals in Cold War Europe have long been considered isolated islands of Central and East European communities with limited relevance. In the second half of the Cold War, some of these periodicals functioned as crucial intersections of ...
doaj   +2 more sources

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