Results 41 to 50 of about 5,270 (307)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Le gouvernement s'inquiète de l'activisme des dissidents

open access: yes, 1995
Béja Jean-Philippe. Le gouvernement s'inquiète de l'activisme des dissidents. In: Perspectives chinoises, n°29, 1995. pp.
Béja, Jean-Philippe
core   +1 more source

97.01 / Exposition des droits des dissidents, joints à ceux de puissances intéressées à les maintenir

open access: yes, 2023
Exposition des droits des dissidents, joints à ceux de puissances intéressées à les ...
Joana Roque Pesquer (16631319)
core   +1 more source

Чешская доля: иллюзии и реальности (полемика Милана Кундеры и Вацлава Гавела)

open access: yesPoznańskie Studia Slawistyczne, 2014
The article is devoted to the analysis of the M. Kundera and V. Havel polemics over the fate and fortunes of the Czech ethnical identity, Czechoslovakian nationhood and ways of Czechoslovakian society development after the August, 1968.
Элла Григорьевна Задорожнюк
doaj   +1 more source

The “textbook Gibson”: The assimilation of dissidence. [PDF]

open access: yesHistory of Psychology, 2015
We examine how the textbooks have dealt with one of psychology's most eminent dissidents, James Gibson (1904-1979). Our review of more than a hundred textbooks, dating from the 1950s to the present, reveals fundamental and systematic misrepresentations of Gibson.
Alan Costall, Paul Morris
openaire   +4 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Parliaments and parliamentarism in the works of Soviet dissidents, 1960s–80s [PDF]

open access: yes, 2019
Drawing from samizdat (self-published) and tamizdat (foreign-published) materials, this article traces the understandings of parliaments and parliamentarism in individual works by Soviet dissidents and reconstructs the authors’ underlying assumptions in ...
Ivan Sablin
core   +1 more source

Brave New World Meets Nineteen Eighty-four in a New Golden Age: On the Passing of Liu Xiaobo, Advent of Big Data, and Resurgence of China as World Power [PDF]

open access: yesContemporary Chinese Political Economy and Strategic Relations: An International Journal, 2018
This paper aims to discuss recent years’ worrying development in the intensified persecution of dissidents in the People’s Republic of China, as most vividly symbolised by the death of the country’s high-profile prisoner of conscience Liu Xiaobo, and the
Emile Kok-Kheng Yeoh
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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