Results 171 to 180 of about 4,672 (301)

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Itaconate mechanism of action and dissimilation in <i>Mycobacterium tuberculosis</i>. [PDF]

Proc Natl Acad Sci U S A
Priya M, Gupta SK, Koundal A, Kapoor S, Tiwari S, Kidwai S, Sorio de Carvalho LP, Thakur KG, Mahajan D, Sharma D, Kumar Y, Singh R.   +11 more
europepmc   +1 more source

An appraisal to Hans Berger by the time of his 150th birthday: the human EEG and tales of blood flow, heat and brain waves. [PDF]

Arq Neuropsiquiatr, 2023
Caeira MW, Caboclo LO, Paola L.
europepmc   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Seeing Bensheim's refugee tent city: reflections on researcher- and respondent-generated photo-elicitation of the spatial dimensions of racial discrimination. [PDF]

Front Sociol
Ba C.
europepmc   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

The Photosynthesis and Respiration Efficiency of <i>Callitriche cophocarpa</i> Sendtn. Under the Stress of Hexavalent Chromium. [PDF]

Int J Mol Sci
Tokarz B, Augustynowicz J, Makowski W, Płachno BJ, Zienkiewicz M, Tokarz KM.   +5 more
europepmc   +1 more source

Predicting the Gas Permeability of Sustainable Cement Mortar Containing Internal Cracks by Combining Physical Experiments and Hybrid Ensemble Artificial Intelligence Algorithms. [PDF]

Materials (Basel), 2023
Chao Z, Yang C, Zhang W, Zhang Y, Zhou J.   +4 more
europepmc   +1 more source

Dissimilation? The Educational Attainment of Second Generation Immigrants [PDF]

The educational attainment of second generation immigrants is of crucial importance for their subsequent labour market success in Germany. While the schooling outcomes of natives improved in recent decades, German-born children of immigrants did not ...
Riphahn, Regina
core  

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source