Results 31 to 40 of about 152,404 (295)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Engineering dissipative quasicrystals

Physical Review B, 2022
We discuss the systematic engineering of quasicrystals in open quantum systems where quasiperiodicity is introduced through purely dissipative processes. While the resulting short-time dynamics is governed by non-Hermitian variants of the Aubry-Andre-Harper model, we demonstrate how phases and phase transitions pertaining to the non-Hermitian ...
Tianyu Li, Yong-Sheng Zhang, Wei Yi
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Energy Dissipation in Hilbert Envelopes on Motion Waveforms Detected in Vibrating Dynamical Systems: An Axiomatic Approach

Communications in Advanced Mathematical Sciences
This paper introduces an axiomatic approach in the theory of energy dissipation in Hilbert envelopes on motion waveforms emanating from various vibrating dynamical systems. A Hilbert envelope is a curve tangent to peak points on a motion waveform.
Tharaka Liyanage, James F. Peters
doaj   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Enhancing Corrosion Resistance and Mechanical Strength of 3D‐Printed Iron Polylactic Acid for Marine Applications via Laser Surface Texturing

Advanced Engineering Materials, EarlyView.
Laser surface texturing significantly improves the corrosion resistance and mechanical strength of 3D‐printed iron polylactic acid (Ir‐PLA) for marine applications. Optimal laser parameters reduce corrosion by 80% and enhance tensile strength by 25% and ductility by 15%.
Mohammad Rezayat, Mojtaba Karamimoghadam, Mohammadreza Lalegani Dezaki, Ali Zolfagharian, Giuseppe Casalino, Antonio Mateo, Mahdi Bodaghi   +6 more
wiley   +1 more source

Advection–Diffusion Lattice Boltzmann Method With and Without Dynamical Filter

Frontiers in Physics, 2022
In multi-component flow and/or thermal flows, when the diffusion coefficient of the advection–diffusion equation is relatively small, the relaxation coefficient in the lattice Boltzmann method will be close to 0.5, which will lead to numerical ...
Zhihong Zhang, Zhiqiang Li, Yunke Wu
doaj   +1 more source

Geometric Optimization and Mechanical Performance Enhancement of Auxetic Structures for High‐Impact Applications Through Fused Deposition Modeling

Advanced Engineering Materials, EarlyView.
This study explores the mechanical performance of three auxetic structures, identifying a re‐entrant‐star hybrid as the most effective for impact absorption. Finite element simulations and experiments demonstrate significant gains in energy absorption and flexural strength after geometric optimization. This study investigates the mechanical performance
Malik Hassan, Manjusri Misra, Alexander Bardelcik, Stefano Gregori, Amar K. Mohanty   +4 more
wiley   +1 more source

Dissipation and mass redistribution as a mechanism of propulsion in closed systems

Revista Brasileira de Ensino de Física
In this work, the mechanism behind motion in closed systems is investigated by studying two simple mechanical systems. Firstly, a simple “ballistic” car system introduces the subject of propulsion as a function of a parameter that modulates the amount of
Ademir L Xavier Jr
doaj   +1 more source