Results 131 to 140 of about 644,654 (317)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Assessment of imputability in a case of murder with dissociation [PDF]
Introduction: Imputability in criminal cases is a main element with regard to possible variations in sentencing with the application of mitigating or exonerating factors, due to the impairment of the cognitive and/or voli tional capacities of the ...
Andrade González, Nelson +5 more
core +1 more source
Posttraumatic stress symptoms, dissociation, and alexithymia in an Italian sample of flood victims [PDF]
, 2014 Giuseppe Craparo,1 Alessio Gori,2 Elvira Mazzola,1 Irene Petruccelli,1 Monica Pellerone,1 Giuseppe Rotondo3 1Faculty of Human and Social Sciences, Kore University of Enna, Enna, Italy; 2Department of Psychology, University of Florence, Florence, Italy ...
Petruccelli I +5 more
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Dissociation and recovery in psychosis – an overview of the literature
Frontiers in PsychiatryBackgroundThe relationship between dissociation and recovery from psychosis is a new topic, which could attract the interest of the researchers in the field of dissociation due to its relevance to their daily clinical practice.
Claudia Calciu +8 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
On Dissociation and Splitting : Normal Dissociation Experiences scale, Fancy Dialogue scale, and Normal Splitting-Projection scale. [PDF]
, 2003 心が統一されていないという現象については, 解離, 抑圧, 分割(分裂, スプリッティング)などの概念によって解明されてきた。これらは, 神経症, 境界パーソナリティ構造, 自己愛パーソナリティなどを説明し, 治療目標を立てる際に有効であった。一方, 概念間の相違はあいまいなままであった。これらを歴史的に明確にしつつ, 解離と分割の概念の類似を論ずる。本論では解離と分割についての創造的側面, 健康な側面について明らかにするとともに「使い分け」とのつながりを示す。そして, 日常的な解離尺度, 空想対話尺度,
1 +3 more
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