Results 111 to 120 of about 13,758 (245)

A quimiometria nos cursos de graduação em química: proposta do uso da análise multivariada na determinação de pkª

Química Nova, 2014
An experiment was proposed applying the Chemometric approach of Multivariate Analysis for inclusion in undergraduate Chemistry courses to promote and expand the use of this analytical-statistical tool. The experiment entails the determination of the acid
Paulo Cesar de Souza Pereira, Camila Fabiano de Freitas, Cristiane Santi Chaves, Bianca Martins Estevão, Diogo Silva Pellosi, André Luiz Tessaro, Vagner Roberto Batistela, Ieda Spacino Scarminio, Wilker Caetano, Noboru Hioka   +9 more
doaj   +1 more source

Femtosecond infrared multiphoton dissociation Workshop report

, 1994
This report contains the extended abstracts of the invited lectures presented at the workshop on 'Femtosecond Infrared Multiphoton Dissociation', held at the Max-Planck-Institut fuer Quantenoptik, July 5-7, 1993.
Max-Planck-Institut fuer Quantenoptik (MPQ), Garching (Germany)
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multi-physics predictive framework for thermolysis of titanium(IV)-isopropoxide

npj Computational Materials
Leveraging high reactivity and volatility of metal-organic (MO) precursors, hybrid molecular beam epitaxy enables precise synthesis of complex oxides with tailored properties.
Benazir Fazlioglu-Yalcin, Cem Sanga, Irem Erpay, Dundar Yılmaz, Adri CT van Duin, Roman Engel-Herbert, Nadire Nayir   +6 more
doaj   +1 more source

Polymer Chemistry

, 2016
Regioselective Michael addition afforded a novel N1-substituted cytosine acrylate monomer for the synthesis of acrylic random copolymers with cytosine pendant groups. Quantitative post-functionalization converted cytosine to ureido-cytosine (UCy) with an
Drummey, Kevin J., Chen, Mingtao, Talley, Samantha J., Moore, Robert Bowen, Zhang, Keren, Long, Timothy E., Anderson, Lindsey J.   +6 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

How Many Drugs Are Catecholics

Molecules, 2007
By examination of the 8659 drugs recorded in the Comprehensive Medicinal Chemistry (CMC) database, 78 catecholics (including five pyrogallolics) were identified, of which 17 are currently prescribed by FDA.
Da-Peng Yang, Hong-Fang Ji, Guang-Yan Tang, Wei Ren, Hong-Yu Zhang   +4 more
doaj   +1 more source

Competitive Ligand Exchange and Dissociation in Ru Indenyl Complexes

, 2018
Kinetic profiles obtained from monitoring the solution phase substitution chemistry of [Ru(η5-indenyl)(NCPh)(PPh3)2]+ (1) by both ESI-MS and 31P{1H} NMR are essentially identical, despite an enormous difference in sample concentrations for these ...
Lars, Yunker, Roman, Belli, J Scott, McIndoe, Yang, Wu, Lisa, Rosenberg, Hyewon, Ji, Anuj, Joshi   +6 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Conformer-specific Infrared spectroscopy of cationic Criegee intermediates syn- and anti-CH3CHOO+

Nature Communications
Criegee intermediates are pivotal in atmospheric chemistry, yet their cationic forms remain poorly understood. This study presents the infrared spectra of cationic Criegee intermediates, specifically syn- and anti-CH3CHOO+, using vacuum ultraviolet ...
Ende Huang, Licheng Zhong, Jingning Xue, Xiaohu Zhou, Siyue Liu, Li Che, Hongwei Li, Hongjun Fan, Wenrui Dong, Xueming Yang   +9 more
doaj   +1 more source