Results 161 to 170 of about 86,679 (262)

Targeting the Protein-Membrane Interface Enables Design of Long-Acting CFTR Potentiators. [PDF]

ACS Chem Biol
Morstein J, Borowsky J, Hu S, Sheen Y, Nisoli V, Hwang TC, Grabe M, Shokat KM.   +7 more
europepmc   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Escaping the Scaling Relationships in Oxygen Reduction Catalysis: Implications for PEM Fuel Cells

Advanced Materials, EarlyView.
Escaping the scaling relationships of the oxygen reduction reaction is vital for hydrogen fuel cells. This outlook examines how interfacial heterogeneity, spanning the subsurface lattice, chemisorption layer, and near‐interface solvation volume, mechanistically decouples intermediate binding energetics.
Muhammad Bilal Wazir, Lourdes F. Vega, Maryam Khaleel   +2 more
wiley   +1 more source

Residue-Level Determination of Small-Molecule-Protein Affinities by Hydrogen-Deuterium Exchange Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Lin, Magalhaes LG, McMillan J, Eadsforth TC, Stewart G, Cartmill KR, Postis VLG, Masson GR.   +7 more
europepmc   +1 more source

Universal Strategy for Phase‐Selective Synthesis of Monolayer TMDs via Colloidal Chemistry

Advanced Materials, EarlyView.
ABSTRACT Colloidal synthesis of monolayer transition metal dichalcogenides (TMDs) remains challenging regarding uniform size, thickness, and crystalline phase. While significant progress has been made in phase engineering, a unified chemical strategy for on‐demand selection of both 2H and 1T′ phases across multiple TMD systems within a single chemical ...
Hoon Ju Lee, Weiguang Yang, Dae Young Park, Mrinal Kanti Kabiraz, Benoit Mahler, Hyeon Suk Shin   +5 more
wiley   +1 more source

Calcium controls type III secretion switch through an SctV-SctW interplay. [PDF]

Front Microbiol
Portaliou AG, Roy P, Parakra R, Bondar AN, Karamanou S, Economou A.   +5 more
europepmc   +1 more source

Soft Skins With Reversible Thickness Morphing: Materials, Mechanisms, and Applications

Advanced Materials, EarlyView.
Evolution of electronic skin (e‐skin) technologies toward adaptive, multifunctional soft skins. Phase I highlights early rigid and discrete sensory interfaces. Phase II shows the transition toward flexible, stretchable, and large‐area e‐skin. Phase III captures the emergence of computational e‐skin.
Oliver Ozioko, Chiamaka Akah, Ravinder Dahiya   +2 more
wiley   +1 more source

Acid Dissociation Constants of Sulfanilamides and Substituent Effect on the Constant

YAKUGAKU ZASSHI, 1964
M, YOSHIOKA, K, HAMAMOTO, T, KUBOTA
openaire   +3 more sources

<i>ortho</i>-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase. [PDF]

RSC Chem Biol
Rowland BE, Roy KD, Alkaş A, Barsoum M, Kuot T, Fuller JC, Naudet AJ, Ospanow E, Jakeman DL.   +8 more
europepmc   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

Advanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà, Giulia Cazzador, Roberta Fabbri, Matteo Calosi, Alessandro Silvestri, Andrea Candini, Fabiola Liscio, Franco Corticelli, Aikaterini Konstantoulaki, Andrea D'Iorio, Marco Caprini, Vincenzo Palermo, Monica Bertoldo, Valentina Benfenati, Chiara Zanardi, Emanuele Treossi   +15 more
wiley   +1 more source