Results 91 to 100 of about 59,210 (303)

The Detection of Dissociative Identity Disorder by Northern Irish Clinical Psychologists and Psychiatrists: A Clinical Vignettes Study

A sample of Northern Irish clinical psychologists (N=27) and psychiatrists (N=29) completed three clinical vignettes designed to assess the detection of dissociative identity disorder.
Dorahy, M J, Lewis, Christopher A, Mulholland, C   +2 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Diagnostic challenges leading to underdiagnosis of dissociative disorders

, 2017
Muhammad Aadil,1 Maria Shoaib2 1Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA; 2Department of medicine, Dow Medical College, Karachi, PakistanWe read the article “Is the Dissociative Experiences Scale able to identify ...
Shoaib M, Aadil M
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Dissociative states in borderline personality disorder and their relationships to psychotropic medication

, 2018
Ondrej Pec,1,2 Petr Bob,1,3 Jakub Simek,1 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 2Psychotherapeutic and ...
Bob P, Simek J, Raboch J, Pec O
core  

Dissociative Disorders

, 2016
We present an overview of major dissociative disorders, including depersonalization/derealization disorder, dissociative amnesia, and dissociative identity disorder. We discuss the prevalence, etiology, and treatment of each disorder and review treatment
Lynn, S. J., Merckelbach, H., Giesbrecht, T., van Heugten-van der Kloet, D., S.O. Lilienfeld, D van Heugten-van der Kloet, T Giesbrecht, Condon, L. P., Lilienfeld, S. O., H Merckelbach, S.J. Lynn, L.P. Condon   +11 more
core   +1 more source

Prospective investigation of positive psychotic symptoms, dissociative symptoms, and metacognitive dysfunctions in a non-clinical population

Scientific Reports
The frequent co-occurrence of positive psychotic and dissociative symptoms in both clinical and non-clinical populations underscores the importance of understanding their interplay for early intervention.
Bryan Ho-wang Yu, Anson Kai Chun Chau, Chui-De Chiu, Suzanne Ho-wai So   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Can dissociative amnesia be a residual symptom of prolonged complex post-traumatic stress disorder?

Annals of General Psychiatry
Background Dissociative amnesia, a disorder characterized by impairments in multiple memory areas, is frequently associated with trauma. Complex post-traumatic stress disorder (CPTSD) is marked by mood dysregulation, negative self-concept, and impaired ...
İzzet Çağrı Metin, Selman Yıldırım, Aykut Karahan   +2 more
doaj   +1 more source