Results 81 to 90 of about 201,896 (330)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Quantum Zeno-based control mechanism for molecular fragmentation [PDF]

, 2012
A quantum control mechanism is proposed for molecular fragmentation processes within a scenario grounded on the quantum Zeno effect. In particular, we focus on the van der Waals Ne-Br$_2$ complex, which displays two competing dissociation channels via ...
A. S. Sanz, Breuer H. P., C. Sanz-Sanz, Cohen-Tannoudji C., O. Roncero, S. Miret-Artés, T. González-Lezana   +6 more
core   +3 more sources

Dissociative symptoms and sleep parameters — an all-night polysomnography study in patients with insomnia

Comprehensive Psychiatry, 2013
Background: Dissociative disorders encompass a range of symptoms varying from severe absent-mindedness and memory problems to confusion about one's own identity.
Dalena Van Der Kloet, Timo Giesbrecht, Erik Franck, Ann Van Gastel, Ilse De Volder, Filip Van Den Eede, Bruno Verschuere, Harald Merckelbach   +7 more
doaj   +1 more source

Atrial Dissociation

Japanese Heart Journal, 1976
Atrial dissociation was recorded in a patient with malignant hypertension and microangiopathic hemolytic anemia. Digitalis intoxication was considered the cause of atrial dissociation.
N, Akatsuka, T, Maekawa, M, Hiraoka
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Anisotropic fragmentation in low-energy dissociative recombination [PDF]

, 2008
On a dense energy grid reaching up to 75 meV electron collision energy the fragmentation angle and the kinetic energy release of neutral dissociative recombination fragments have been studied in a twin merged beam experiment.
A Petrignani, A S Jaroshevich, A Wolf, B Jordon-Thaden, Bardsley J N, C Krantz, D A Orlov, D Schwalm, D Shafir, D Zajfman, F O Waffeu Tamo, F O Waffeu Tamo, H Buhr, H Rubinstein, I F Schneider, J Hoffmann, M B Mendes, M Froese, M Grieser, M H Berg, M Lange, M Lestinsky, O Novotný, Orlov D A, S Novotny, Schneider I F, Shafir D, Takagi H   +27 more
core   +1 more source

The Role of Dissociative Compartmentalization in Difficult-to-Treat Psychotic Phenomena

Frontiers in Psychology, 2021
Cate Treise, Jesus Perez, Jesus Perez, Jesus Perez   +3 more
doaj   +1 more source

Neuro-Cognition in adolescents with dissociative disorder: A study from a Tertiary Care Center of North India

Indian Journal of Psychological Medicine, 2019
Background: Dissociative disorder is a common neurotic disorder. Patients with dissociative disorder experience significant psychological distress and have deficits in various domains of neurocognitive functions.
Ayushi Dixit, Shweta Singh, Sujita K Kar, Amit Arya, Vivek Agarwal   +4 more
doaj   +1 more source