Results 41 to 50 of about 3,088 (284)

Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association Mensuração da atividade sérica de marcadores de lesão cardíaca em cadelas anestesiadas com cetamina S(+), atropina e xilazina

Acta Cirúrgica Brasileira, 2009
PURPOSE: To assessment of the aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme fraction MB (CK-MB) serum activity in female dogs anesthetized with ketamine S (+), atropine and xylazine in several associations. METHODS:
Leandro Guimarães Franco, Maria Clorinda Soares Fioravanti, Adilson Donizeti Damasceno, Aline Cardoso Borges, Lorena Karine Soares, Rogério Elias Rabelo, Luiz Antônio Franco da Silva   +6 more
doaj   +1 more source

Syntheses, analytical and pharmacological characterizations of the “legal high” 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues [PDF]

New psychoactive substances (NPS) are commonly referred to as “research chemicals”, “designer drugs” or “legal highs.” One NPS class is represented by dissociative anesthetics, which include analogues of the arylcyclohexylamine phencyclidine (PCP ...
Aguayo, Aguayo, Ahmadi, Bailey, Bailey, Bradford, Brady, Brandt, Brine, Cheng, Cone, Cone, Elliott, Felsby, Geneste, Gintzler, Helander, Ho, Hugel, Iadarola, Kalir, Katritzky, Lipton, Maddox, Marquis, Martin, McCann, McLaughlin, McMillan, Michely, Morris, Newport, Overton, Parsons, Parsons, Pud, Rammes, Reynolds, Reynolds, Roth, Sang, Su, Su, Thomas, Vaupel, Wallach, Wallach, Wallach, West, Zukin, Zukin   +50 more
core   +1 more source

Treatment-resistant major depression: Rationale for NMDA receptors as targets and nitrous oxide as therapy [PDF]

, 2015
Major depressive disorder (MDD) remains a huge personal and societal encumbrance. Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression (TMRD), which afflicts 15–30% of MDD patients.
Conway, Charles R, Mennerick, Steven, Nagele, Peter, Zorumski, Charles F   +3 more
core   +2 more sources

Clinical Electroencephalography for Anesthesiologists [PDF]

, 2017
The widely used electroencephalogram-based indices for depth-of-Anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics.
Brown, Emery Neal, Pavone, Kara J., Purdon, Patrick L., Sampson, Aaron   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution

Frontiers in Human Neuroscience, 2017
There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the dissolution of the sense of self and the loss of boundaries between self and world.
Raphaël Millière
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efeitos hemodinâmicos e termorregulatórios da mistura cetamina-xilasina persistem mesmo após o período anestésico em ratos [PDF]

, 2012
The xylazine-ketamine mixture (KX) is an anesthetic approach commonly administered to assess cardiovascular function in rodents. This study aimed to examine if the cardiovascular and thermoregulatory effects of KX could persist after the anesthetic state
Antonio, Ednei Luiz, Levy, Rozeli Ferreira, Picollo, Camila, Santos, Leonardo dos, Serra, Andrey Jorge, Tucci, Paulo José Ferreira   +5 more
core   +4 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Low-dose Ketamine Does Not Improve Migraine in the Emergency Department: A Randomized Placebo-controlled Trial

Western Journal of Emergency Medicine, 2018
Introduction: Patients frequently present to the emergency department (ED) with migraine headaches. Although low-dose ketamine demonstrates analgesic efficacy for acute pain complaints in the ED, headaches have historically been excluded from these ...
Ashley R. Etchison, Lia Bos, Meredith Ray, Kelly B. McAllister, Moiz Mohammed, Barrett Park, Allen Vu Phan, Corey Heitz   +7 more
doaj   +1 more source