Results 51 to 60 of about 18,428 (291)

Dissociation and Dissociative Disorders Reconsidered

Annual Review of Clinical Psychology, 2022
For more than 30 years, the posttraumatic model (PTM) and the sociocognitive model (SCM) of dissociation have vied for attention and empirical support. We contend that neither perspective provides a satisfactory account and that dissociation and dissociative disorders (e.g., depersonalization/derealization disorder, dissociative identity disorder) can ...
Lynn, Steven Jay, Polizzi, Craig, Merckelbach, Harald, Chiu, Chui-De, Maxwell, Reed, van Heugten, Dalena, Lilienfeld, Scott O   +6 more
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Elektra complex in dissociative identity disorder: A case report

European Psychiatry, 2021
Introduction Dissociative identity disorder is a quite popular psychiatric diagnosis in general public but in actuality has a very low prevalence rate.
P. Jain, V. Mudgal, U. Sardesai, V. Pal
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cortisol secretion in children with symptoms of reactive attachment disorder [PDF]

, 2013
Maltreated children with Reactive Attachment Disorder (RAD) have severe problems with social relationships and affect regulation. An association between early maltreatment and changes in the daily rhythm of cortisol secretion has already been reported ...
Kocovska, E., Follan, M., Gillberg, Christopher, Gillberg, C., Wallace, A.M., Puckering, C., Gorski, C., Follan, Michael, Young, D., Smillie, M., Minnis, H., Barnes, J., Gorski, Charlotta, Wallace, Alan Michael, Barnes, James, Wilson, P., Kocovska, Eva, Wilson, Philip, Minnis, Helen, Smillie, Maureen, Puckering, Christine, Young, David   +21 more
core   +1 more source

Can dissociative amnesia be a residual symptom of prolonged complex post-traumatic stress disorder?

Annals of General Psychiatry
Background Dissociative amnesia, a disorder characterized by impairments in multiple memory areas, is frequently associated with trauma. Complex post-traumatic stress disorder (CPTSD) is marked by mood dysregulation, negative self-concept, and impaired ...
İzzet Çağrı Metin, Selman Yıldırım, Aykut Karahan   +2 more
doaj   +1 more source

A Non-linear Predictive Model of Borderline Personality Disorder Based on Multilayer Perceptron

Frontiers in Psychology, 2018
Borderline Personality Disorder is a serious mental disease, classified in Cluster B of DSM IV-TR personality disorders. People with this syndrome presents an anamnesis of traumatic experiences and shows dissociative symptoms.
Nelson M. Maldonato, Raffaele Sperandeo, Enrico Moretto, Silvia Dell'Orco   +3 more
doaj   +1 more source