Results 71 to 80 of about 18,428 (291)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Malingering Dissociative Identity Disorder: Objective and Projective Assessment

, 2002
Verification of dissociative identity disorder presents challenges given the complex nature of the illness. This study addressed the concern that this disorder can be successfully malingered on objective and projective psychological tests.
Susan M. Labott, Heather R. Wallach
core   +1 more source

Psychiatric Comorbidity in Patients with Conversion Disorder and Prevalence of Dissociative Symptoms [PDF]

, 2015
The 1st objective of the current study was to investigate the frequency and types of dissociative symptoms in patients with conversion disorder (CD). The 2nd objective of the current study was to determine psychiatric comorbidity in patients with and ...
Tekin, Atilla, Karamustafalioglu, Oguz, Tankaya, Onur, Bakim, Bahadir, Ozer, Omer Akil, Ertekin, Hulya, Yayla, Sinan   +6 more
core   +1 more source

An explorative study on emotional dysregulation in dissociative disorder

Telangana Journal of Psychiatry
Background: Dissociative Disorder is a complex phenomenon related to stress which started from period of adolescence marks the shift from childhood to adulthood and marked by physical, psychological, social, and emotional changes.
Neeru Saini, Indira Bhowmick, Pradeep Kumar   +2 more
doaj   +1 more source

First Reported Case of Lorazepam-Assisted Interview in a Young Indian Female Presenting with Dissociative Identity Disorder and Improvement in Symptoms after the Interview

Case Reports in Psychiatry, 2014
Dissociative identity disorder (DID) is one of the most fascinating disorders in psychiatry. The arduous search to reveal the obscurity of this disorder has led to colossal research in this area over the years.
Raheel Mushtaq, Sheikh Shoib, Tasleem Arif, Tabindah Shah, Sahil Mushtaq   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Detection of Dissociative Identity Disorder by Northern Irish Clinical Psychologists and Psychiatrists: A Clinical Vignettes Study

A sample of Northern Irish clinical psychologists (N=27) and psychiatrists (N=29) completed three clinical vignettes designed to assess the detection of dissociative identity disorder.
Dorahy, M J, Lewis, Christopher A, Mulholland, C   +2 more
core   +1 more source

Dissociative disorder after traumatic brain injury

, 1999
Several episodes of dissociative disorder, including depersonalisation and multiple personality, have been observed in a 32-year old man during a period of a few months following a mild traumatic brain injury.
CANTAGALLO, Anna, GRASSI, Luigi, DELLA SALA S.   +2 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source