Results 71 to 80 of about 1,098,265 (205)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The state scale of dissociation : development, psychometric validation, and application in a study of concurrent electro-encephalographic correlates [PDF]

The distinction between state and trait dissociation informed the development and psychometric validation of the State Scale of Dissociation (SSD) and the study of concurrent electro-encephalographic (EEG) correlates of experimentally induced ...
Krüger, Christina
core  

Long-term outcome and prognosis of dissociative disorder with onset in childhood or adolescence

Child and Adolescent Psychiatry and Mental Health, 2008
Background In the majority of cases short-term treatment outcome of juvenile dissociative disorder is rather favourable. In contrast, the long-term course seems to be less positive, but meaningful results are still fragmentary.
Wewetzer Christoph, Ellgring Heiner, Schneider Wolfgang, Weigand Tobias, Schneck-Seif Stefanie, Jans Thomas, Warnke Andreas   +6 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Psychotherapy and Pharmacotherapy for Patients With Dissociative Identity Disorder

, 2013
There is a wide variety of what have been called dissociative disorders, including dissociative amnesia, dissociative fugue, depersonalization disorder, dissociative identity disorder, and forms of dissociative disorder not otherwise specified. Some of
Dillon, Kristy, Gentile, Julie, Gillig, Paulette Marie   +2 more
core   +2 more sources

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Effectiveness of phase-oriented treatment for trauma-related dissociative disorders: a systematic review

European Journal of Psychotraumatology
Background: Dissociative disorders (DDs) are a group of mental health conditions characterised by disconnection from thoughts, feelings, memories, or sense of identity.
Thomas A. Griffiths, Lora I. Dimitrova, Mark Linington, Devin B. Terhune, Antje A. T. S. Reinders   +4 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Stressful Life Events, Personality Profile, Emotional Maturity, Coping Strategies, Expressed Emotions, and Vulnerability in Patients with Somatoform Disorder and Dissociative Disorder: A Cross-sectional Comparative Study

Journal of Psychiatry Spectrum
Background: The relationship between somatoform and dissociative disorders is complex, involving overlapping influences of personality traits, illness perception, emotional processing, familial influences, stress, and coping.
Jitendra Jeenger, Anjali Sharma
doaj   +1 more source