Results 71 to 80 of about 46,948 (289)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Recurrent dissociative fugue

Indian Journal of Psychological Medicine, 2013
Dissociative fugue is a rarely reported diagnostic entity. It is one of the least understood and yet clinically one of the most fascinating disorders in mental health.
Abhishek Mamarde, Praveen Navkhare, Amrita Singam, Akash Kanoje   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Dissociative Experiences, childhood trauma and alexithymia among mothers of children with autism spectrum disorder

Neuropsychiatric Investigation, 2017
Dissociative Experiences, childhood trauma and alexithymia among mothers of children with autism spectrum disorder Objective: Previous studies have consistently pointed out that parents of children with autism spectrum disorder (ASD) had worse mental
Mesut Işık, Abdullah Yıldırım, Murat Boysan, Duygu Murat   +3 more
doaj   +1 more source

Psychopathological risk in parentally bereaved adolescents [PDF]

, 2016
For a child, the death of a parent is a traumatic experience and can give rise to several difficulties during the child’s development. International literature in this field has focused on clinical populations; evaluations of the psychological ...
BALLAROTTO, GIULIA, CERNIGLIA, LUCA, CIMINO, SILVIA, ERRIU, MICHELA   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

An explorative study on emotional dysregulation in dissociative disorder

Telangana Journal of Psychiatry
Background: Dissociative Disorder is a complex phenomenon related to stress which started from period of adolescence marks the shift from childhood to adulthood and marked by physical, psychological, social, and emotional changes.
Neeru Saini, Indira Bhowmick, Pradeep Kumar   +2 more
doaj   +1 more source

Dissociative Identity Disorder Of Main Character In Sybil Novel By Flora R. S Based On Psychological Perspective [PDF]

, 2016
Sybil novel tells about woman that has sixteen personalities. This novel is very interesting because there is a psychology aspect in this novel. The writer intends to find out the characterization of the sixteen personalities and psychological problems ...
Mirani, R. (Rizky)
core  

On the Plausibility of Idealism: Refuting Criticisms [PDF]

, 2017
Several alternatives vie today for recognition as the most plausible ontology, from physicalism to panpsychism. By and large, these ontologies entail that physical structures circumscribe consciousness by bearing phenomenal properties within their ...
Kastrup, Bernardo
core   +2 more sources