Results 201 to 210 of about 2,065,779 (288)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Secondary Ion-Ice Chemistry in UV-Irradiated Oxygen Ice: New Astrochemical Models Including Bulk Ionic Species. [PDF]

ACS Earth Space Chem
Darnell K, Lopez-Sanders D, Warren D, Carroll RA, Stanley E, Majumdar L, Caselli P, Arumainayagam CR, Shingledecker CN.   +8 more
europepmc   +1 more source

Synergistic NiO‐NiCo Heterostructure Electrode for Highly Active and Durable Hydrogen Evolution in Industrial Alkaline Water Electrolysis

Advanced Science, EarlyView.
This study presents a NiO–NiCo heterostructure electrode that enhances water dissociation and hydrogen adsorption through synergistic interfacial interactions, verified by electrochemical and spectroscopic analyses. Its high performance in a large‐area single‐cell system under dynamic conditions demonstrates how rational non‐precious catalyst design ...
Jinwoo Lee, Kyungbeen Yeom, Gaeun Hong, Yoojin Shin, Ji Seong Hyoung, Ji Eun Park, Heonjoong Lee, Taeyang Han, Yung‐Eun Sung, Jeong Won Kang, Kyoung‐Soo Kang, Hyunjoon Lee   +11 more
wiley   +1 more source

Electron attachment to CH₃COCl molecule and clusters. [PDF]

RSC Adv
Kocábková B, Ďurana J, Rakovský J, Poterya V, Fárník M, Gatt M, Schöpfer G, Jung P, Ončák M.   +8 more
europepmc   +1 more source

Piezo‐Coupling Effects in Smart Polymers: Toward Ultrasensitive Sensing and Biomedical Applications

Advanced Science, EarlyView.
Piezo‐coupling effects are the foundational factors for the development of multifunctional and self‐powered platforms. Central to this advancement is the use of stimuli‐responsive smart polymers, which offer mechanical flexibility, biocompatibility, and simplified structural complexity with improved sensitivity and energy efficiency.
Duc Khanh Tran, Tuan Sang Tran, Thanh‐An Truong, Trung‐Hieu Vu, That Buu Ton, Dzung Viet Dao, Van Thanh Dau   +6 more
wiley   +1 more source

Focused electron beam-induced deposition from Ru(CO)₄(fumaronitrile): incomplete carbonyl loss and nitrogen retention. [PDF]

Eur Phys J D At Mol Opt Phys
Jureddy CS, Chaudhary A, Singh R, McElwee-White L, Utke I.   +4 more
europepmc   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Electron-Induced Fragmentation of 5-Iodouridine: Implications for Enhanced Radiotherapy. [PDF]

J Phys Chem Lett
Kopyra J, Wierzbicka P, Abdoul-Carime H.
europepmc   +1 more source

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source

Cluster Anions of Hydrated Polycyclic Aromatic Hydrocarbons: "Magic" Water Tetramer. [PDF]

J Phys Chem A
Ďurana J, Kocábková B, Pysanenko A, Pluhařová E, Fedor J, Fárník M.   +5 more
europepmc   +1 more source