Results 41 to 50 of about 5,296 (287)

Dissociative identity disorder: Out of the shadows at last? [PDF]

open access: yes, 2021
Dissociative identity disorder (DID) is a severely debilitating disorder. Despite recognition in the current and past versions of the DSM, DID remains a controversial psychiatric disorder, which hampers its diagnosis and treatment.
Reinders, Antje A. T. S.   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

“Who am I?” The HiddenAspects of Dissociative Identity Disorder

open access: yesJournal of Bahria University Medical and Dental College
Dissociative identity disorder (DID) is a persistent posttraumatic condition marked by impaired memory and selfidentity functions resulting from childhood trauma.
Alishba Eman
doaj   +1 more source

Dissociative Identity Disorder [PDF]

open access: yes, 2022
The diagnosis of 'Multiple Personality Disorder' has been changed to 'Dissociative Identity Disorder' because this phenomenon is not only about a person having split, multiple personalities, but also about what they are experiencing in terms of the ...
Ramirez, Brianna
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

FOUR SELVES OF A STUDENT – A CASE REPORT OF DISSOCIATIVE IDENTITY DISORDER [PDF]

open access: yesPsychiatria Fennica, 2021
Dissociative identity disorder’s origin is often traced back to early traumatization. This disorder is difficult to diagnose within a short appointment, and the patient may appear psychotic.
Henna Haravuori, MD, PhD   +4 more
doaj  

Dissociative part-dependent resting-state activity in dissociative identity disorder: a controlled FMRI perfusion study. [PDF]

open access: yesPLoS ONE, 2014
BackgroundIn accordance with the Theory of Structural Dissociation of the Personality (TSDP), studies of dissociative identity disorder (DID) have documented that two prototypical dissociative subsystems of the personality, the "Emotional Part" (EP) and ...
Yolanda R Schlumpf   +5 more
doaj   +1 more source

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