Results 71 to 80 of about 22,096 (288)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Convergent validity of the new form of the DES [PDF]

, 1994
p. 101-103The line and circle farms of the Dissociative Experiences Scale (DES I and DES II) were administered to 65 subjects in the general population, 87 subjects with a clinical diagnosis of dissociative identity disorder, and 26 subjects with a ...
Ellason, Joan W., Mayran, Lawrence W., Ross, Colin A., Sainton, Kelly   +3 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Dissociation and pain perception : an experimental investigation [PDF]

, 2006
textDissociative symptoms and abnormalities in pain perception have been associated with a range of disorders. We tested whether experimentally induced increases in state dissociation would cause an analgesic response, and whether this effect would be ...
Horowitz, Jonathan David
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effectiveness of phase-oriented treatment for trauma-related dissociative disorders: a systematic review

European Journal of Psychotraumatology
Background: Dissociative disorders (DDs) are a group of mental health conditions characterised by disconnection from thoughts, feelings, memories, or sense of identity.
Thomas A. Griffiths, Lora I. Dimitrova, Mark Linington, Devin B. Terhune, Antje A. T. S. Reinders   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Psychodynamic Insights and Approach to a Case of Dissociative Identity Disorder

Journal of the Scientific Society
Dissociative identity disorder (DID) is characterized by disruptions in identity, presenting as two or more distinct personality states often associated with early trauma. This case study examines a 20-year-old woman with DID, who experienced alternating
Stuti Sharma, Sameeran S. Chate, Vinayak Koparde   +2 more
doaj   +1 more source

Political mobilisation by minorities in Britain: negative feedback of ‘race relations'? [PDF]

, 1999
This article uses a political opportunity approach to study the relationship of minority groups to the political community in Britain. The main argument is that the British race relations approach established in the 1960s had an important effect that ...
Brubaker R., Castles S., Eder K., Favell A., FitzGerald M., Geddes A., Goulbourne H., Hutnik N., Ireland P., Jones T., Koopmans R., Koopmans R., Kriesi H., Kymlicka W., Layton‐Henry Z., Mason D., McAdam D., Melucci A., Modood T., Modood T., Modood T., Modood T., Modood T., Modood T., Parekh B., Paul Statham, Poulter S., Rex J., Rex J., Rucht D., Sewell T., Shukra K., Skellington R., Solomos J., Soysal Y.N., Tarrow S., Tarrow S., Werbner P., Young I.M.   +38 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source