Results 141 to 150 of about 2,605 (250)

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Entanglement and electronic coherence in attosecond molecular photoionization. [PDF]

Nature
Koll LM, Suñer-Rubio AJ, Witting T, Bello RY, Palacios A, Martín F, Vrakking MJJ.   +6 more
europepmc   +1 more source

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

Advanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh, Dominik Havlicek, Andrea Galisova, Ondrej Sedlacek, Daniel Jirak   +4 more
wiley   +1 more source

Photodissociation and electron-collision induced dissociation of C₅H₂F₁₀ using photoelectron-photoion coincidence spectroscopy and quantum chemistry. [PDF]

Sci Rep
Tran NT, Hayashi T, Iwayama H, Ishikawa K.   +3 more
europepmc   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Sequential dissociation of ionized benzonitrile

The authors are grateful for valuable discussions with Anita Dawes at the OU. The expert technical support provided by T. Webley, K. Dewar, A. Maldonado, and their colleagues at the OU is acknowledged. The OU’s logistical and financial support is also acknowledged, including fund- ing DBD’s PhD studentship. S.E. acknowledges the British EPSRC’s support
Debes, DB, Mendes, M, Rodrigues, R, Ameixa, J, Cornetta, LM, da Silva, FF, Eden, S   +6 more
openaire   +1 more source

IR-Action Spectroscopy of the Astrochemically Relevant HCCS⁺ Cation. [PDF]

ACS Earth Space Chem
Michielan M, Steenbakkers K, Ascenzi D, Diprose JA, Polášek M, Brünken S, Romanzin C, Heazlewood BR, Puzzarini C, Richardson V.   +9 more
europepmc   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Dissociative Electron Attachment to 8-(Trifluoromethyl)thioadenine: A Potential Radiosensitizer. [PDF]

J Phys Chem B
Szczyrba A, Datta M, Makurat S, Chen J, Biernacki K, Demkowicz S, Denifl S, Rak J.   +7 more
europepmc   +1 more source