Results 111 to 120 of about 371,966 (313)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

DISOLUCIJA SFRJ I OBNOVA NEZAVISNOSTI BOSNE I HERCEGOVINE NA STRANICAMA LISTA „OSLOBOĐENJE“ // DISSOLUTION OF YUGOSLAVIA AND THE RENEWAL OF BOSNIA AND HERZEGOVINA'S INDEPENDENCE ON THE PAGES OF „OSLOBOĐENJE“ [PDF]

open access: yesHistorijski pogledi, 2018
The author of the paper deals with the research and study of the process of the dissolution of the former SFRY, and the restoration of the independence of Bosnia and Herzegovina, through the pages of the daily newspaper Oslobodjenje.
Omer Zulić
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES

open access: yesVitae, 2011
Propranolol-HCl is a non selective β-adrenergic blocker widely used in the treatment of several cardiovascular diseases; nevertheless, the physicochemical information about its volumetric behavior and other aqueous properties is not complete at present ...
Daniel Ricardo DELGADO   +2 more
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

The dissolution of gold colloids in aqueous thiosulfate solutions

open access: yes, 2008
The kinetics of the dissolution of gold and silver colloids in ammoniacal thiosulfate solutions has been studied using oxygen, copper(II) or oxygenated copper(II) as oxidants at pH 9 - 11 and temperature 22oC to 48oC.
Zhang, Xinmin
core  

Statistical Properties of the Dissolution Test of USP [PDF]

open access: yes, 2004
The dissolution test as defined in the United States Phar-macopoeia (1) is used in judging the quality of pharma-ceutical products. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved
Carlos D. Saccone   +3 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Does cohabitation prior to marriage raise the risk of marital dissolution and does this effect vary geographically? [PDF]

open access: yes
A number of studies show that premarital cohabitation increases the risk of subsequent marital dissolution. Some argue that this is a consequence of selection effects and that once these are controlled for premarital cohabitation has no effect on ...
Paul J. Boyle, Hill Kulu
core  

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