Results 51 to 60 of about 909,392 (302)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine) [PDF]

, 2007
Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica.
Yousef Javadzadeh, Jafari-Navimipour, Baharak, Javadzadeh, Yousef, Yousef Javadzadeh (16203113), Baharak Jafari-Navimipour (16203116), Ali Nokhodchi, Baharak Jafari-Navimipour, Nokhodchi, Ali, Ali Nokhodchi (4465915)   +8 more
core   +1 more source

Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system

Acta Pharmaceutica
Oral solid dosage forms are most frequently administered with a glass of water which empties from the stomach relatively fast, but with a certain variability in its emptying kinetics.
Felicijan Tjaša, Bogataj Marija
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Disintegration, In vitro Dissolution, and Drug Release Kinetics Profiles of k-Carrageenan-based Nutraceutical Hard-shell Capsules Containing Salicylamide

Open Chemistry, 2020
The release of drugs from solid drug delivery materials has been studied intently in recent years. Quantitative analyses achieved from in vitro dissolution becomes easier if a zero-order mathematical model is used.
Pudjiastuti Pratiwi, Wafiroh Siti, Hendradi Esti, Darmokoesoemo Handoko, Harsini Muji, Fauzi M. Al Rizqi Dharma, Nahar Lutfun, Sarker Satyajit D.   +7 more
doaj   +1 more source

Oxidative dissolution of Cr-doped UO2 nuclear fuel

npj Materials Degradation, 2023
Alternative UO2 nuclear fuels, incorporating Cr as a dopant, are currently in use in light–water reactors. Dissolution experiments using Cr-doped UO2, performed as a function of Cr content in a simplified groundwater solution and under oxic conditions ...
Hannah Smith, Théo Cordara, Clémence Gausse, Sarah E. Pepper, Claire L. Corkhill   +4 more
doaj   +1 more source

Predicting Dissolution Kinetics of Tricalcium Silicate Using Deep Learning and Analytical Models

Algorithms, 2022
The dissolution kinetics of Portland cement is a critical factor in controlling the hydration reaction and improving the performance of concrete. Tricalcium silicate (C3S), the primary phase in Portland cement, is known to have complex dissolution ...
Taihao Han, Sai Akshay Ponduru, Arianit Reka, Jie Huang, Gaurav Sant, Aditya Kumar   +5 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Clustered Single Cellulosic Fiber Dissolution Kinetics and Mechanisms through Optical Microscopy under Limited Dissolving Conditions [PDF]

, 2018
Herein, we describe a new method of assessing the kinetics of dissolution of single fibers by dissolution under limited dissolving conditions. The dissolution is followed by optical microscopy under limited dissolving conditions.
Ulla Holopainen-Mantila, Ronny Wahlström (5081339), Holopainen-Mantila, Ulla, Wahlström, Ronny; id_orcid, King, Alistair W. T., Holopainen-Mantila, Ulla; id_orcid, Wahlström, Ronny, Kilpeläinen, Ilkka, Valtteri Mäkelä, Alistair W. T. King (1680475), Ulla Holopainen-Mantila (1945657), Alistair W. T. King, King, Alistair W T, Ilkka Kilpeläinen (1680472), Ilkka Kilpeläinen, Mäkelä, Valtteri, Ronny Wahlström, Valtteri Mäkelä (5081342)   +17 more
core   +1 more source