Results 51 to 60 of about 1,965,906 (302)
SeparationsThe biological activities of curcuminoids, the main polyphenol constituents of Curcuma longa (turmeric), have been the subject of many studies in recent years.
Andrea Mariela Araya-Sibaja +5 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Dissolution Stability Study of Cefadroxil Extemporaneous Suspensions [PDF]
, 2008 Dissolution studies have become matter of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process.
Noelia L. Gonzalez Vidal +8 more
core +1 more source
Asian Journal of Pharmaceutical Sciences, 2017 The purpose of this study was to develop an extended-release (ER) matrix tablet that shows robust dissolution properties able to account for the variability of pH and mechanical stress in the GI tract using a combination of enteric polymer and ...
Sachiko Fukui +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
ESTUDOS DA QUALIDADE DE COMPRIMIDOS E CÁPSULAS CONTENDO AMINOFILINA
Eclética Química, 2018 Asthma is a chronic inflammatory disease characterized by impairment of the lower airways. Theophylline has been used to treat asthma and their preparation for therapeutic purposes is aminophylline.
Marcelo Antonio de Oliveira +5 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Dissolution of Cavities and Porous Media: a Multi-Scale View [PDF]
, 2013 Dissolution of underground cavities or porous media involves many different scales that must be taken into account in modeling attempts. This paper presents a review of some of these problems.
Quintard, Michel
core
The influence of fillers on theophylline release from clay matrices [PDF]
, 2015 : The objectives of this study were to investigate the suitability of magnesium aluminium silicate (MAS) (Veegum®) to control drug release of a model drug, theophylline, from tablet matrices.
Asare-Addo, Kofi +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source