Results 91 to 100 of about 11,632,967 (345)

Solid Dispersions of Genistein via Solvent Rotary Evaporation for Improving Solubility, Bioavailability, and Amelioration Effect in HFD-Induced Obesity Mice

Pharmaceutics
Genistein (GEN) is an active pharmaceutical ingredient that presents the challenges of poor water solubility and low oral bioavailability.
Chenxu Qiu, Yancui Zhang, Yingsai Fan, Shupeng Li, Jianting Gao, Xin He, Xinghua Zhao   +6 more
doaj   +1 more source

Study of the impact of different salts on the intrinsic dissolution rate of pharmaceutical compounds [PDF]

, 2017
The intrinsic dissolution rate (IDR) of a free base and its four salts were investigated with the aim of selecting the salt with the best dissolution performance.
Box, Karl, Lee, Sam, Outhwaite, Breeze, Ruiz, Rebeca   +3 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Self-discharge in bimetallic cells containing alkali metal [PDF]

, 1969
Theoretical analysis of thermally regenerative bimetallic cells with alkali metal anodes shows a relation between the current drawn and the rate of discharge under open-circuit conditions. The self-discharge rate of the cell is due to the dissolution and
Foster, M. S., Hesson, J. C., Shimotake, H.   +2 more
core   +1 more source

Distribution of carbonate in surface sediments of the Pacific Ocean [PDF]

, 1976
The distribution of carbonate on the floor of the Pacific has been remapped on the basis of 1313 points from 80 references stored in the World Ocean Sediment Data Bank of Scripps Institution of Oceanography. Percent distribution maps and carbonate versus
Adelseck, Charles, Berger, W. H., Mayer, Larry A.   +2 more
core   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Investigation of the in vitro performance difference of drug-Soluplus® and drug-PEG 6000 dispersions when prepared using spray drying or lyophilization

Saudi Pharmaceutical Journal, 2017
Purpose: To evaluate the physicochemical and in vitro characteristics of solid dispersions using BCS II model drugs with Soluplus® and one of its component homopolymers, PEG 6000.
Mohammad A. Altamimi, Steven H. Neau
doaj   +1 more source

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The star cluster formation history of the LMC

, 2012
The Large Magellanic Cloud is one of the nearest galaxies to us and is one of only few galaxies where the star formation history can be determined from studying resolved stellar populations.
Anders, Baumgardt, Baumgardt, Bertelli, Bica, Binney, Boutloukos, Boutloukos, Chandar, Chandar, Chiosi, Clauset, de Grijs, de Vaucouleurs, E. K. Grebel, Fukui, G. Parmentier, Gieles, Gieles, Gieles, Girardi, Girardi, Glatt, Gnedin, Goddard, Goodwin, H. Baumgardt, Harris, Hills, Holtzman, Hughes, Hughes, Hunter, King, Kroupa, Kroupa, Lamers, Lamers, Lamers, Mackey, Marigo, Maschberger, Meatheringham, Milone, Olsen, Olszewski, Ostriker, P. Anders, Padoan, Parmentier, Parmentier, Parmentier, Piatti, Pietrzynski, Piskunov, Popescu, Solomon, Spitzer, Udalski, van der Marel, van der Marel, Vesperini, Vesperini, Weinberg, Weinberg, Wielen, Zaritsky, Zaritsky   +67 more
core   +1 more source