Results 91 to 100 of about 555,478 (356)

Sensitivity of dissolution rate to location in the paddle dissolution apparatus

Journal of Pharmacy and Pharmacology, 2002
Abstract The aim of the present study was to determine the apparent diffusion boundary layer and dissolution rate constant for various surfaces of compacts and at various locations in the USP paddle dissolution apparatus. Benzoic acid compacts were coated with paraffin wax leaving only the surface under investigation free for dissolution.
A M, Healy, L G, McCarthy, K M, Gallagher, O I, Corrigan   +3 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
doaj   +1 more source

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation [PDF]

, 2015
Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems.
Benda L., FRANCESCHINIS, ERICA, Perssutti B., REALDON, NICOLA, SANTOMASO, ANDREA CLAUDIO, Voinovich D.   +5 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The star cluster formation history of the LMC

, 2012
The Large Magellanic Cloud is one of the nearest galaxies to us and is one of only few galaxies where the star formation history can be determined from studying resolved stellar populations.
Anders, Baumgardt, Baumgardt, Bertelli, Bica, Binney, Boutloukos, Boutloukos, Chandar, Chandar, Chiosi, Clauset, de Grijs, de Vaucouleurs, E. K. Grebel, Fukui, G. Parmentier, Gieles, Gieles, Gieles, Girardi, Girardi, Glatt, Gnedin, Goddard, Goodwin, H. Baumgardt, Harris, Hills, Holtzman, Hughes, Hughes, Hunter, King, Kroupa, Kroupa, Lamers, Lamers, Lamers, Mackey, Marigo, Maschberger, Meatheringham, Milone, Olsen, Olszewski, Ostriker, P. Anders, Padoan, Parmentier, Parmentier, Parmentier, Piatti, Pietrzynski, Piskunov, Popescu, Solomon, Spitzer, Udalski, van der Marel, van der Marel, Vesperini, Vesperini, Weinberg, Weinberg, Wielen, Zaritsky, Zaritsky   +67 more
core   +1 more source

Formulation and Evaluation of a Furosemide Nanosuspension Using High-Pressure Homogenization for Enhanced Dissolution Rate

, 2022
Mital Patel, Piyush Patel
openalex   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3 [PDF]

, 2010
double Holliday junction (dHJ) is a central intermediate of homologous recombination that can be processed to yield crossover or non-crossover recombination products. To preserve genomic integrity, cells possess mechanisms to avoid crossing over. We show
C Gaillard, CF Chen, Csanad Z Bachrati, CZ Bachrati, CZ Bachrati, FG Harmon, FG Harmon, G Ira, HL Klein, Ian D Hickson, J German, J Plank, JC Wang, JC Wang, JK Karow, JL Plank, JL Plank, JL Plank, Jody L Plank, JR Mullen, L Bell, L Wu, L Wu, M Bzymek, M Chang, N Kantake, P Cejka, Petr Cejka, R Hanai, RS Chaganti, S Gangloff, S Raynard, S Raynard, Stephen C Kowalczykowski, TA Shapiro, TJ Fu, W Bussen, WD Heyer   +37 more
core   +2 more sources

Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation

, 2022
Alexandre Machado Rubim, Jaqueline Bandeira Rubenick, Marcela Maurer, Luciane Varini Laporta, Clarice Madalena Bueno Rolim   +4 more
openalex   +1 more source