Results 41 to 50 of about 39,337 (267)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
D-bounded Distance-regular Graphs
European Journal of Combinatorics, 1997 Let \(\Gamma\) be a distance-regular graph of diameter \(D\geq 3\). The paper gives all basic facts from the literature and all necessary notions, e.g. the notion of weak-geodetically closed subgraph of \(\Gamma\), the notion of \(D\)-bounded graph, etc. Let \(P(\Gamma)\) denote the poset the elements of which are the weak-geodetically closed subgraphs
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Parallelogram-Free Distance-Regular Graphs
Journal of Combinatorial Theory, Series B, 1997 This paper deals with distance-regular graphs. It is shown that a distance-regular graph with certain properties has classical parameters \((d,b,\alpha,\beta)\) with ...
Liang, Yuh-jeng, Weng, Chih-wen
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Distance-Regular Graphs and Halved Graphs
European Journal of Combinatorics, 1986 Let G be a bipartite distance-regular graph with bipartition \(V(G)=X\cup Y\). Let \(V(G')=X\) and, for x and y in X, let x be adjacent to y in G' if and only if x is of distance two from y in G. Then G' is called a halved graph of G, and is distance-regular. This paper discusses whether G' is one of the known, large-diameter, distance-regular graphs.
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On 3-Chromatic Distance-Regular Graphs [PDF]
SSRN Electronic Journal, 2006 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Blokhuis , A. +2 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A flocking algorithm for multi-agent systems with connectivity preservation under hybrid metric-topological interactions. [PDF]
PLoS ONE, 2018 In this paper, we propose a connectivity-preserving flocking algorithm for multi-agent systems in which the neighbor set of each agent is determined by the hybrid metric-topological distance so that the interaction topology can be represented as the ...
Chenlong He, Zuren Feng, Zhigang Ren
doaj +1 more source
Addressing graph products and distance-regular graphs
Discrete Applied Mathematics, 2017 Graham and Pollak showed that the vertices of any connected graph $G$ can be assigned $t$-tuples with entries in $\{0, a, b\}$, called addresses, such that the distance in $G$ between any two vertices equals the number of positions in their addresses where one of the addresses equals $a$ and the other equals $b$.
Sebastian M. Cioabă +4 more
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source