Results 61 to 70 of about 263,414 (258)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Domination Numbers in Graphs Resulting from Shackle Operations with Linkage of any Graph

JTAM (Jurnal Teori dan Aplikasi Matematika)
The domination number is the number of dominating nodes in a graph that can dominate the surrounding connected nodes with a minimum number of dominating nodes. This domini number is denoted by γ(G). In this research, we will examine the domination number
Ilham Saifudin, Triyanna Widiyaningtyas, Rohmad Wahid Rhomdani, Moh. Dasuki   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Domination in distance-hereditary graphs

Discrete Applied Mathematics, 2002
A linear time algorithm for the domination problem on distance-hereditary graphs is given.
Chang, M.S., Wu, S.C., Yeh, H.G., Chang, G.J.   +3 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Graphs with Large Disjunctive Total Domination Number

, 2014
Let $G$ be a graph with no isolated vertex. In this paper, we study a parameter that is a relaxation of arguably the most important domination parameter, namely the total domination number, $\gamma_t(G)$.
Henning, Michael A., Naicker, Viroshan
core   +2 more sources

On signed distance-k-domination in graphs [PDF]

Czechoslovak Mathematical Journal, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Xing, Huaming, Sun, Liang, Chen, Xuegang
openaire   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Injective Eccentric Domination in Graphs

مجلة بغداد للعلوم
The concept of domination has inspired researchers which has contributed to a vast literature on domination. A subset  of  is said to be a dominating set, if every vertex not in  is adjacent to at least one vertex in .
Riyaz Ur Rehman A, A Mohamed Ismayil
doaj   +1 more source

A note on a Vizing's generalized conjecture [PDF]

Opuscula Mathematica, 2007
In this note we give a generalized version of Vizing's conjecture concerning the distance domination number for the cartesian product of two graphs.
Mostafa Blidia, Mustapha Chellali
doaj