Results 91 to 100 of about 4,831,666 (266)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Signed distance function implicit geologic modeling
REM: International Engineering JournalPrior to every geostatistical estimation or simulation study there is a need for delimiting the geologic domains of the deposit, which is traditionally done manually by a geomodeler in a laborious, time consuming and subjective process.
Roberto Mentzingen Rolo +2 more
doaj +1 more source
The geography of banking power: role of function distance
PSL Quarterly Review, 2012 In this paper we analyse the new geography of the Italian banking system on the basis of the integration pressures of recent years. The analysis of the evolution of the banking system is focused on the concept of distance.
Pietro Alessandrini +2 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Distance-Based Relevance Function for Imbalanced Regression
StatsImbalanced regression poses a significant challenge in real-world prediction tasks, where rare target values are prone to overfitting during model training. To address this, prior research has employed relevance functions to quantify the rarity of target
Daniel Daeyoung In, Hyunjoong Kim
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The Bifixation Field as a Function of Viewing Distance
Journal of Ophthalmology, 2014 Hering reported that the area over which he could bifixate a target was smaller at near convergence distances than far convergence distances and predicted that in extreme horizontal gaze positions, the temporally directed eye lags behind the nasally ...
Philip M. Grove +2 more
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Generalized Quadratic Revenue Functions [PDF]
In this paper we focus on specification of revenue functions in their dual price space. We consider two distance functions, both dual to the revenue function: Shephard output distance function and the directional output distance function, both in price ...
Michael Vardanyan +3 more
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Remarks on the hardy inequality
Journal of Inequalities and Applications, 1997 Let be an open subset of with finite Lebesgue -measure, let be the distance from to the boundary of , and let . We give a simple direct proof that if satisfies the plumpness condition of Martio and Väisälä [10], then the inequality ...
Hurri–Syrjänen R, Edmunds DE
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