Results 91 to 100 of about 4,822,734 (285)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Signed distance function implicit geologic modeling
REM: International Engineering JournalPrior to every geostatistical estimation or simulation study there is a need for delimiting the geologic domains of the deposit, which is traditionally done manually by a geomodeler in a laborious, time consuming and subjective process.
Roberto Mentzingen Rolo +2 more
doaj +1 more source
The geography of banking power: role of function distance
PSL Quarterly Review, 2012 In this paper we analyse the new geography of the Italian banking system on the basis of the integration pressures of recent years. The analysis of the evolution of the banking system is focused on the concept of distance.
Pietro Alessandrini +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Distance-Based Relevance Function for Imbalanced Regression
StatsImbalanced regression poses a significant challenge in real-world prediction tasks, where rare target values are prone to overfitting during model training. To address this, prior research has employed relevance functions to quantify the rarity of target
Daniel Daeyoung In, Hyunjoong Kim
doaj +1 more source
The Bifixation Field as a Function of Viewing Distance
Journal of Ophthalmology, 2014 Hering reported that the area over which he could bifixate a target was smaller at near convergence distances than far convergence distances and predicted that in extreme horizontal gaze positions, the temporally directed eye lags behind the nasally ...
Philip M. Grove +2 more
doaj +1 more source
Unsigned Distance Functions (UDFs) can be used to represent non-watertight surfaces in a deep learning framework. However, UDFs tend to be brittle and difficult to learn, in part because the surface is located exactly where the UDF is non-differentiable.
Le, Hieu +3 more
openaire +2 more sources
Generalized Quadratic Revenue Functions [PDF]
In this paper we focus on specification of revenue functions in their dual price space. We consider two distance functions, both dual to the revenue function: Shephard output distance function and the directional output distance function, both in price ...
Michael Vardanyan +3 more
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