Results 61 to 70 of about 832,958 (281)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Variation of sum of two largest eigenvalues of the distance matrices of four-leaf graph

open access: yesJournal of Hebei University of Science and Technology, 2020
In order to accurately obtain the extremum of the distance eigenvalues of fowr-leaf graphs under tow graph transformations in any case, two graph transformations of four-leaf graphs and the results of the above problems were given by using the properties
Zhe LYU, Yubin GAO
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Metrics for Single-Edged Graphs over a Fixed Set of Vertices

open access: yesMathematical and Computational Applications, 2018
Graphs have powerful representations of all kinds of theoretical or experimental mathematical objects. A technique to measure the distance between graphs has become an important issue.
Ray-Ming Chen
doaj   +1 more source

Orientable -distance magic regular graphs

open access: yesAKCE International Journal of Graphs and Combinatorics, 2021
Hefetz, Mütze, and Schwartz conjectured that every connected undirected graph admits an antimagic orientation (Hefetz et al., 2010). In this paper we support the analogous question for distance magic labeling. Let be an Abelian group of order .
Paweł Dyrlaga, Karolina Szopa
doaj   +1 more source

On Domination Number and Distance in Graphs [PDF]

open access: yes, 2014
A vertex set $S$ of a graph $G$ is a \emph{dominating set} if each vertex of $G$ either belongs to $S$ or is adjacent to a vertex in $S$. The \emph{domination number} $\gamma(G)$ of $G$ is the minimum cardinality of $S$ as $S$ varies over all dominating ...
Kang, Cong X.
core  

Hardness of Exact Distance Queries in Sparse Graphs Through Hub Labeling

open access: yes, 2019
A distance labeling scheme is an assignment of bit-labels to the vertices of an undirected, unweighted graph such that the distance between any pair of vertices can be decoded solely from their labels.
Alstrup S.   +5 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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