Results 81 to 90 of about 832,958 (281)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
On the distance eigenvalues of Cayley graphs
پژوهشهای ریاضی, 2022 In this paper, graphs are undirected and loop-free and groups are finite. By Cn, Kn and Km,n we mean the cycle graph with n vertices, the complete graph with n vertices and the complete bipartite graph with parts size m and n, respectively.
Majid Arezoomand
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
On Wiener index of graph complements [PDF]
Transactions on Combinatorics, 2014 Let $G$ be an $(n,m)$-graph. We say that $G$ has property $(ast)$ if for every pair of its adjacent vertices $x$ and $y$, there exists a vertex $z$, such that $z$ is not adjacent to either $x$ or $y$.
Jaisankar Senbagamalar +2 more
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Structural Relationship of Isomorphic Graph and its Mapping to Hamming Distance [PDF]
EPJ Web of ConferencesMapping graph isomorphism to Hamming distance enables a simple yet effective approach to quantifying structural similarity. By encoding graphs as binary adjacency vectors—flattened from the upper triangle of the adjacency matrix—structural comparisons ...
Tiwari Monika +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Universal distance domination in random graphs
Miskolc Mathematical NotesGiven a graph G=(V,E)D⊆VV∖DDGγ(G)GkDDdDk uk(G):= min {d:∀ D⊆V with |D|≥d,D is a kdd set in G}.kuk(G)γ(G)=u1(G)ukkkkH ...
Gábor Bacsó +2 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source