Results 41 to 50 of about 1,934,842 (247)
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Advanced Science, EarlyView.In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Single‐atom growth from [Zr@Sb12]2− to [Zr@Sb13]3− disrupts the closed‐shell S2P6 superatomic configuration and markedly attenuates three‐dimensional (3D) aromaticity. Ultrafast spectroscopy further links stronger spherical aromaticity to slower excited‐state relaxation, establishing an atom‐resolved structure‐aromaticity‐dynamics relationship ...
Yun Zhang +7 more
wiley +2 more sources
Constant Sum Partition of Sets of Integers and Distance Magic Graphs
Discussiones Mathematicae Graph Theory, 2018 Let A = {1, 2, . . . , tm+tn}. We shall say that A has the (m, n, t)-balanced constant-sum-partition property ((m, n, t)-BCSP-property) if there exists a partition of A into 2t pairwise disjoint subsets A1, A2, . . . , At, B1, B2, . . .
Cichacz Sylwia, Gőrlich Agnieszka
doaj +1 more source
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.Alkoxy side chains regulate hydrazone‐linked COF nanochannel microenvironments by tuning pore polarity, reactant adsorption, and charge‐separation behavior. The optimized framework facilitates oxygen activation and hydrogen peroxide photosynthesis in real water and a 1 L natural‐sunlight reactor. LCA further shows that natural sunlight and larger‐scale
Ruixue Sun +11 more
wiley +2 more sources
Distance magic labelings of product graphs
, 2017 21 pages, the Second Malta Conference in Graph Theory and ...
Simanjuntak, Rinovia +1 more
openaire +2 more sources
On Reverse Super Vertex-Magic Labeling [PDF]
, 2018 For a graph G(V, E) an injective mapping f from to the set is a reverse vertex-magic labeling if there is a constant h so that for every vertex where the difference runs over all vertices u adjacent to v . A vertex-magic labeling f is called super vertex-
, U. Masthan Raju, Shaik Sharief Basha
core +1 more source
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Uniform core‐shell colloidal particles of Covalent Organic Frameworks (COFs) are synthesized by a seeded growth of electron‐acceptor COF shells on electron‐donor COF cores. The resulting p‐n heterojunction enables efficient separation of photogenerated charges, which persist for minutes. These core‐shell COFs show efficient CO2 photoreduction to CO and
Ting Yu +8 more
wiley +2 more sources