Results 111 to 120 of about 601,118 (351)

Development of a Real Time Sparse Non-Negative Matrix Factorization Module for Cochlear Implants by Using xPC Target [PDF]

, 2013
Cochlear implants (CIs) require efficient speech processing to maximize information transmission to the brain, especially in noise. A novel CI processing strategy was proposed in our previous studies, in which sparsity-constrained non-negative matrix ...
Mark Lutman, Bleeck, S., Hu, Hongmei, Lutman, M.E., Agamemnon Krasoulis, Krasoulis, A., Hongmei Hu, Stefan Bleeck   +7 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A distance geometry-based description and validation of protein main-chain conformation

IUCrJ, 2017
Understanding the protein main-chain conformational space forms the basis for the modelling of protein structures and for the validation of models derived from structural biology techniques. Presented here is a novel idea for a three-dimensional distance
Joana Pereira, Victor S. Lamzin
doaj   +1 more source

Comparing representational geometries using whitened\n unbiased-distance-matrix similarity [PDF]

, 2020
Jörn Diedrichsen, Eva Berlot, Marieke Mur, Heiko H. Schütt, Mahdiyar Shahbazi, Nikolaus Kriegeskorte   +5 more
openalex   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Bayesian Estimation of A Distance Functional Weight Matrix Model [PDF]

This paper considers the distance functional weight matrix in spatial autoregressive and spatial error models from a Bayesian point of view. We considered the Markov chain Monte Carlo methods to estimate the parameters of the models.
Kazuhiko Kakamu
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The distance matrix and its variants for graphs and digraphs [PDF]

, 2022
The distance matrix $\mathcal{D}(G)$ of a connected graph $G$ is the matrix whose entries are the pairwise distances between vertices. The distance matrix was defined by Graham and Pollak in 1971 in order to study the problem of loop switching in routing
Reinhart, Carolyn
core   +1 more source

A unified approach to protein domain parsing with inter-residue distance matrix. [PDF]

Bioinformatics, 2023
Zhu K, Su H, Peng Z, Yang J.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source