Results 31 to 40 of about 547,023 (266)

Basic Input Data for Audiences’ Geotargeting by Destinations’ Partial Accessibility: Notes from Slovakia

open access: yesData, 2023
The presented notes focus partially on two of the basic elements (accessibility and image) of any managed tourism destination from the perspective of basic ETL processes over open and third-party data.
Csaba Sidor   +2 more
doaj   +1 more source

On Matrix Nearness Problems: Distance to Delocalization [PDF]

open access: yesSIAM Journal on Matrix Analysis and Applications, 2015
Summary: In this paper we introduce a new matrix nearness problem that is intended to generalize the distance to instability. Due to its applicability in analyzing the robustness of eigenvalues with respect to the arbitrary localization sets (domains) in the complex plane, we call it the distance to delocalization.
Vladimir R. Kostić   +2 more
openaire   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

On spectral radius of the generalized distance matrix of a graph [PDF]

open access: yesDiscrete Mathematics Letters, 2021
Shariefuddin Pirzada
doaj   +1 more source

Support Values for Genome Phylogenies

open access: yesLife, 2016
We have recently developed a distance metric for efficiently estimating the number of substitutions per site between unaligned genome sequences. These substitution rates are called “anchor distances” and can be used for phylogeny reconstruction.
Fabian Klötzl, Bernhard Haubold
doaj   +1 more source

Classified AGV Material Flow and Layout Data Set for Multidisciplinary Investigation

open access: yesIEEE Access, 2023
Automated Guided Vehicles (AGV) are increasingly used in industry to automate material flow tasks. To efficiently operate systems of AGVs, researchers have proposed many different planning and control methods, e.g., for scheduling, dispatching, and ...
Marvin Sperling   +4 more
doaj   +1 more source

Factoring distance matrix polynomials

open access: yesDiscrete Mathematics, 1993
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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