Results 111 to 120 of about 5,398,404 (309)

Distance decay in activity chains analysis. A Belgian case study [PDF]

This paper aims at measuring and testing the distance decay effect in activity chains. It enables one to show how far distance constrains the length of the trips and if there are borders effects.
Ann Verhetsel, Isabelle Thomas, Hakim Hammadou, Dries Vanhofstraeten   +3 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Experience with support services of graduate students with disabilities studying at a distance: A Case study

, 2008
This study examines the characteristics of graduate students with disabilities studying at a distance and their experience with formal disability-specific support services.
Brown, V. M.
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Management of Distance Education: IEC Modules

This report on Management of Distance Education consists of the following: Unit 11 Applying research to running an institution, UNIT 12 Assessment of distance education, UNIT 13 Managing the institution, UNIT 14 Budgeting and costs, UNIT 16 Managing ...
The Distance Education Centre of the University of the West Indies and The International Extension College
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Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins. [PDF]

J Am Chem Soc, 2023
Yang Z, Stein RA, Pink M, Madzelan P, Ngendahimana T, Rajca S, Wilson MA, Eaton SS, Eaton GR, Mchaourab HS, Rajca A.   +10 more
europepmc   +1 more source

The preliminary successes and drawbacks of a turn to distance design studio learning.

, 2020
It seems the technological campuses of tomorrow have manifested today as an essential and spontaneous response to the COVID-19 world outbreak. This article briefly discusses the current pivot from an on-campus physical design studio curriculum towards a ...
Marshalsey, Lorraine
core  

Determination of Right Ventricular Volume by Combining Echocardiographic Distance Measurements

, 2016
Background: The position of the right ventricle (RV), often partly behind the sternum, implies difficulties to image the RV free wall using transthoracic echocardiography (TTE) and consequently limits the possibilities of stroke volume calculations.
Thunberg, Per,, Waldenborg, Micael,, Lidén, Mats,, Wodecki, Maciej,, Per Thunberg, Stina Jorstig, Mats Lidén, Micael Waldenborg, Hellstrandh Jorstig, Stina,, Maciej Wodecki   +9 more
core   +1 more source