Results 121 to 130 of about 10,336,803 (378)
A dust-parallax distance of 19 megaparsecs to the supermassive black hole in NGC 4151
, 2014 The active galaxy NGC 4151 has a crucial role as one of only two active galactic nuclei for which black hole mass measurements based on emission line reverberation mapping can be calibrated against other dynamical methods.
A Pancoast +38 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Estimasi Jarak Genetik antar Domba Garut Tipe Tangkas dengan Tipe Pedaging
Media Peternakan, 2007 The objectives of the present study were to estimate the genetic distance and to determine the discriminant variables among fighting and meat types sheep of Garut (Garut sheep). A total of 413 heads of Garut sheep from five sub-populations were used in
S.S. Mansjoer +2 more
doaj
DISTANCE MEASURING DEVICE AND DISTANCE MEASURING METHOD
, 2018 A distance measuring device includes a light emission portion for emitting light; a light receiving portion for receiving measurement light that is emitted by the light emission portion and reflected by a measurement object, the light receiving portion comprising a plurality of pixels, each pixel having at least one light receiving portion and ...
Y. Matsui +4 more
openaire +2 more sources
Trigonometric Parallaxes for 1,507 Nearby Mid-to-Late M-dwarfs
, 2013 The MEarth survey is a search for small rocky planets around the smallest, nearest stars to the Sun as identified by high proper motion with red colors. We augmented our planetary search time series with lower cadence astrometric imaging and obtained two
Berta-Thompson, Zachory K. +3 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Agricultural Machinery, 2015 Electronic canopy characterization to determine structural properties is an important issue in tree crop management. Ultrasonic and optical sensors are the most used sensors for this purpose. The objective of this work was to assess the performance of an
H Maghsoudi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source