Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The spatial effect of protein deuteration on nitroxide spin-label relaxation : Implications for EPR distance measurement [PDF]
This work was supported by a Wellcome Trust Senior Fellowship (095062) to T.O.-H. The Authors would also like to acknowledge funding from The MRC – United Kingdom, Grant G1100021.Pulsed electron-electron double resonance (PELDOR) coupled with site ...
Ward, Richard +9 more
core +1 more source
A fuzzy directional distance measure [PDF]
Proceedings of the 2014 World Congress on Computational Intelligence (WCCI 2014), pp.
Josie C. McCulloch +3 more
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
An investigation with multiparameter on hip roenıgenograms of normal infanıs
A total of 6868 measurement on 414 hips of 207 normal child {95 (45.9%) boys and 112 (54.1%) girls] were evaluated in this study. AU length and its relation with epiphyses of femoral head was determined in order to achieve the diagnosis of developmental ...
Fuat Akpınar +6 more
doaj
On measuring the distance between histograms [PDF]
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sung-Hyuk Cha, Sargur N. Srihari
openaire +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Exploring A Transactional Distance-Based Management Model To Improve Perception Of Efficacy Within Designated Corporate Collaboration Communities [PDF]
Oil and Gas (O&G) companies are adopting blended learning models to move away from traditional face-to-face training programs that are viewed as costly and less efficient.
Workman, Timothy Peter
core
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Flexible Pedagogy, Flexible Practice: Notes from the Trenches of Distance Education [PDF]
Flexibility has become a watchword in modern education, but its implementation is by no means a straightforward matter. Flexible Pedagogy, Flexible Practice sheds light on the often taken-for-granted assumptions that inform daily practice and examines ...
Elizabeth Burge +2 more
core

