Results 41 to 50 of about 1,899,876 (238)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
On Reading Reading: Fundamental Problems of “Méta-lecture”
On_CultureIn his essay “Sur la Lecture,” Roland Barthes (1984) expresses his doubts regarding what he calls “Méta-lecture,” or the reading of reading. It is nothing but “un éclat d’idées, de craintes, de désirs, de jouissances, d’oppressions.” My essay ...
Elias Kreuzmair
doaj +1 more source
Reseña de Underwood, Ted: “Distant Horizons. Digital evidence and literary change”
Revista de Humanidades Digitales, 2019 Esta reseña evalúa el trabajo más reciente de Ted Underwood: “Distant Horizons. Digital evidence and literary change”, publicado en 2019 por la Universidad de Chicago.
Laura Jiménez Ríos
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
About distant and close reading
, 2019 Po didžiojo pasakojimo krizės į humanitarinius mokslus, atrodo, ateina ir nuoseklaus skaitymo praktikos saulėlydis. Tradicinis atidus skaitymas priskiriamas „teksto malonumui“, kuris priešinamas teksto supratimui, įmanomam tik...
Keturakis, Saulius
core +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Rencontres et réceptions avec Marine Picon : quel est le fondement de la connaissance ?
Lexicon PhilosophicumThe purpose of this note is to explore the theme of language as an object of reception, to highlight the interrelationship between some key concepts, and to sketch, however briefly, a conceptual thread that will allow us to present some of the points of ...
Cristina Marras
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source