Results 61 to 70 of about 1,899,876 (238)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Close Reading – Distant Reading. Spannungsfelder der slavistischen Literatur- und Kulturwissenschaften

, 2021
Reflexionen des Gesellschaftlichen in Sprache und Literatur. Hallesche Beiträge. Band 9: Close Reading – Distant Reading. Spannungsfelder der slavistischen Literatur- und Kulturwissenschaften. Junges Forum Slavistische Literaturwissenschaft 2019 in Halle
Khrushcheva, Daria, Schäfer, Christiane, Chertenko, Alexander, Drosihn, Yvonne, Bachmaier, Annelie, Houfková, Kateřina, Stadlinger, Elisabeth, Savrova, Yultuz, Hakobyan, Sofi, Schmitt, Angelika, Kowollik, Eva, Salzer, Angelika, Alpermann, Marie-Luise, Tretakov, Alexandra, Lazičić, Goran, Delić, Zlatan, Kozakova, Slata, Spodarets, Galyna, Koch, Franziska, Matijević, Tijana, Sulikowska-Fajfer, Joanna, Beridze, Irine, Jakóbczyk, Adrianna   +22 more
core   +1 more source

The Emergence of Quantitative Studies. Actual Functionalities and the Romanian Case

Metacritic Journal for Comparative Studies and Theory, 2018
The aim of this essay is to examine the evolution of quantitative studies and the changes that occurred within their usage, portraying the international case as well as debating upon the existence and the relevance of a Romanian case. Given the fact that
Mihnea Bâlici
doaj   +1 more source

Producing social mobility. Class and Travel in the Romanian Novel 1901-1932

Metacritic Journal for Comparative Studies and Theory, 2020
The present article addresses the Romanian novelistic production between 1901 and 1932 in the attempt of identifying a series of patterns regarding the protagonists’ social mobility.
Ovio Olaru
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Distant reading of The Lord of the Rings: visualization and statistical analyses of its character network

Complex & Intelligent Systems
Distant reading is a computational framework in literary studies that employs algorithms to automatically extract and analyze complex information from literary works.
N.-S. Huang, R. Chen, C.-M. Chen
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Should we write about history, or about doing history?

Lychnos, 2023
This article explores diverging ways of accounting for methodological questions in the history writing digital history on one hand, and Swedish history of ideas (idéhistoria) on the other.
Jacob Orrje
doaj