Results 61 to 70 of about 188,127 (258)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Enhancing yeast alcohol production during red sorghum (Sorghum bicolor L. Moench) wort fermentation

AMB Express
The fermentation of sorghum wort is one of the fundamental steps that determine the quality of this beer. It is influenced by several parameters, among others: temperature, pH, sugar content, amino acid profile, phenolic compound content, and redox ...
Arthur K. Amisi, Jean-Claude T. Bwanganga   +1 more
doaj   +1 more source

Design Considerations of a Simplified Multiple Dividing Wall Column Pilot Plant

ChemEngineering, 2019
This contribution elaborates the design considerations of a simplified version of a four-product multiple dividing wall column in pilot plant scale that will be built at Ulm University.
Ulrich Preißinger, Lena-Marie Ränger, Thomas Grützner   +2 more
doaj   +1 more source

Unassisted and Carbon Dioxide-Assisted Hydro- and Steam-Distillation: Modelling Kinetics, Energy Consumption and Chemical and Biological Activities of Volatile Oils

Pharmaceuticals, 2022
The demand for more suitable eco-friendly extraction processes has grown over the last few decades and driven research to develop efficient extraction processes with low energy consumption and low costs, but always assuring the quality of the volatile ...
Sara El-Kharraf, Soukaïna El-Guendouz, Farah Abdellah, El Mestafa El Hadrami, Alexandra M. Machado, Cláudia S. Tavares, Ana Cristina Figueiredo, Maria Graça Miguel   +7 more
doaj   +1 more source

Survey on Knowledge Distillation for Large Language Models: Methods, Evaluation, and Application [PDF]

ACM Transactions on Intelligent Systems and Technology
Large Language Models (LLMs) have showcased exceptional capabilities in various domains, attracting significant interest from both academia and industry.
Chuanpeng Yang, Yao Zhu, Wang Lu, Yidong Wang, Qian Chen, Chenlong Gao, Bingjie Yan, Yiqiang Chen   +7 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Digital Twin in Modelling Citronella Grass Essential Oil Distillation Process with Computational Fluid Dynamics Approach

Journal of Applied Agricultural Science and Technology
This study aims to investigate distillation process of Citronella Grass (Cymbopogon nardus) essential oil and determine the effect of heating temperature on oil quality, which significantly influences the market value.
Arifia Noor Riwanti, Budi Hermana
doaj   +1 more source