Results 131 to 140 of about 445,292 (276)

Neighbouringhood distinguishing colourings of graphs [PDF]

open access: yes, 2020
A thesis submitted in partial fulfilment of the requirements for the degree of Master of Science (Mathematics)In this mini thesis, we study neighbourhood distinguishing colouring (NDC) of graphs, which are proper colourings of the vertices with the added
Nafuka, Helena N
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Distinguishing infinite graphs [PDF]

open access: yes, 2007
The distinguishing number D(G) of a graph G is the least cardinal number @ such that G has a labeling with @ labels that is only preserved by the trivial automorphism. We show that the distinguishing number of the countable random graph is two, that tree-
Vladimir Trofimov   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The Distinguishing Number of Some Special Kind of Graphs [PDF]

open access: yes
In the present study, the distinguishing number of some different graphs is examined where different graphs like the coconut tree graph, firecracker graph, jellyfish graph, triangular book graph, and banana tree graph have been taken into account.
Sharma, Amit, Salat, Arti
core   +1 more source

Distinguishing captive-reared from wild Kemp's Ridleys [PDF]

open access: yes, 1997
6 pages; available for download at the link below.In 1996, the U.S. National Marine Fisheries Service's (NMFS) Galveston Laboratory, Gladys Porter Zoo (GPZ, Brownsville, Texas USA) and Instituto Nacional de la Pesca (INP) of Tamaulipas, Mexico.
Eckert, Karen L., Eckert, Scott A.
core  

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