Results 51 to 60 of about 86,396 (265)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Operating Properties of the Inductive Current Transformer and Evaluation of Requirements for Its Compliance with the IEC 61869-1 WB2 Class Extension for Frequency up to 20 kHz

Energies
Nanocrystalline material provides an opportunity to improve the wideband performance of inductive current transformers and enables the possibility of ensuring their transformation accuracy for distorted and sinusoidal current from 50 Hz up to 20 kHz ...
Michal Kaczmarek
doaj   +1 more source

An Artificial Neural Network Developed in MATLAB-Simulink for Reconstruction a Distorted Secondary Current Waveform. Part 1

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2021
Recently, there has been an increased interest in the use of artificial neural networks in various branches of the electric power industry including relay protection.
Yu. V. Rumiantsev, F. A. Romaniuk
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Analysis of Current Distortion of Three-Phase Voltage Source Rectifiers and its Application in Fault Diagnosis

IEEE Access, 2020
The open-switch fault of three-phase voltage source rectifiers (VSR) may lead to ac current distortion. In the past decade, some current-based fault diagnosis methods have been proposed, which directly used the phenomenon of current distortion but lacked
Chunsong Sui, Yigang He, Mingyun Chen
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An Improved Current Control Strategy for a Grid-Connected Inverter under Distorted Grid Conditions

Energies, 2016
This paper presents an improved current control strategy for a three-phase grid-connected inverter under distorted grid conditions. The main challenge associated with the grid-connected inverter in distributed generation (DG) systems is to maintain the ...
Ngoc Bao Lai, Kyeong-Hwa Kim
doaj   +1 more source

A Model Predictive Current Control Method for Achieving a High Efficiency and High Robustness Boost PFC Converter Operation

IEEE Access, 2023
This paper proposes a boost PFC converter based on model predictive current control to achieve both improved efficiency and robustness against voltage distortion.
Hyeon-Joon Ko, Hyun-Gyu Koh, Yeong-Jun Choi   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source