Results 111 to 120 of about 1,104,579 (342)

Perancangan Sistem Pakar Fuzzy Multi-Attribute Decision Making Psychological Distress pada Generasi Millennials

open access: yesJurnal Eksplora Informatika, 2019
Psychological distress adalah keadaan subjektif yang dipresepsikan tidak menyenangkan. Setiap manusia tidak bisa menghindari dari gejala psychological distress yang meliputi depresi kecemasan ataupun stress, termasuk pada generasi millenials Generasi ...
Putri Taqwa Ningrum   +2 more
doaj   +1 more source

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

open access: yesThe Lancet Respiratory Medicine, 2020
Zhe Xu   +17 more
semanticscholar   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

open access: yesAdvanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo   +6 more
wiley   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

open access: yesAdvanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv   +11 more
wiley   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

open access: yesAdvanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang   +16 more
wiley   +1 more source

The relationship between distress tolerance and life satisfaction among young adults in Saudi Arabia

open access: yesFrontiers in Psychology
PurposeThis study examined the relationship between Distress Tolerance, defined as the individual’s ability to withstand psychological stress or endure negative emotions, and Life Satisfaction, the cognitive component of the individual’s subjective ...
Hala Abd Ellatif Elsayed   +1 more
doaj   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

open access: yesAdvanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen   +4 more
wiley   +1 more source

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