Results 61 to 70 of about 1,841,492 (309)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Climate change distress and impairment in Germany

open access: yesFrontiers in Public Health
IntroductionClimate change has been widely recognized as one of the most challenging problems facing humanity and it imposes serious mental health threats.
Lars König   +6 more
doaj   +1 more source

The crisis “Archetypogram” – of prisoners, soldiers, sages and jesters

open access: yesThe Asia Pacific Scholar, 2021
Introduction: Archetypes in psychology are complete models of behaviours, thoughts and feelings, representative of universal experiences. From Plato’s description of Forms to Jung’s analytical introduction to archetypes in psychology, to common use of ...
Rahman Habeebul
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

The relationship between distress tolerance and life satisfaction among young adults in Saudi Arabia

open access: yesFrontiers in Psychology
PurposeThis study examined the relationship between Distress Tolerance, defined as the individual’s ability to withstand psychological stress or endure negative emotions, and Life Satisfaction, the cognitive component of the individual’s subjective ...
Hala Abd Ellatif Elsayed   +1 more
doaj   +1 more source

Socio-cultural factors surrounding mental distress during the perinatal period in Zambia: a qualitative investigation. [PDF]

open access: yes, 2012
BACKGROUND: The presence of mental distress during pregnancy and after childbirth imposes detrimental developmental and health consequences for families in all nations.
Dixey, R   +3 more
core   +2 more sources

Dialysis Distress

open access: yesJournal of the Pakistan Medical Association
This communication conceptualizes and characterizes thephenomenon of dialysis distress, commonly encounteredin persons living with end stage kidney disease on dialysis.Dialysis distress can be defined as an emotional state,marked by extreme apprehension, anxiety, despair and/ordejection, due to a perceived inability to cope with thechallenges and ...
Sanjay Kalra   +2 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Existential distress in cancer: Alleviating suffering from fundamental loss and change [PDF]

open access: yes, 2018
A severe life threatening illness can challenge fundamental expectations about security, interrelatedness with others, justness, controllability, certainty, and hope for a long and fruitful life.
Kissane, David, Vehling, Sigrun
core   +2 more sources

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