Results 71 to 80 of about 1,307,492 (288)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The effect of teacher collaboration on teachers' career well-being in China: A moderated mediation model of teacher self-efficacy and distributed leadership

Acta Psychologica
The mechanisms and boundary conditions through which teacher collaboration influences teachers career well-being remain insufficiently explored. To address this gap, this study aimed to examine the relationship between teacher collaboration and teachers'
Guangqiang Wang, Hui Bai, Kwok Kuen Tsang, Jinjin Bian   +3 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Development of Grid e-Infrastructure in South-Eastern Europe

, 2011
Over the period of 6 years and three phases, the SEE-GRID programme has established a strong regional human network in the area of distributed scientific computing and has set up a powerful regional Grid infrastructure.
A Balaž, Antun Balaž, B Novaković, Boro Jakimovski, C Ozturan, D Davidović, D Syrakov, Dušan Vudragović, Emanouil Atanassov, I Vidanović, I Vidanović, IE Stanković, Ioannis Liabotis, K Lagouvardos, Mihajlo Savić, MV Milovanović, Ognjen Prnjat, V Kotroni, Vladimir Slavnić   +18 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Wireless Device-to-Device Communications with Distributed Caching

, 2012
We introduce a novel wireless device-to-device (D2D) collaboration architecture that exploits distributed storage of popular content to enable frequency reuse.
Dimakis, Alexandros G., Golrezaei, Negin, Molisch, Andreas F.   +2 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Collaboration technology and space science [PDF]

A summary of available collaboration technologies and their applications to space science is presented as well as investigations into remote coaching paradigms and the role of a specific collaboration tool for distributed task coordination in supporting ...
Brown, R. L., Haines, R. F., Leiner, Barry M.   +2 more
core   +1 more source

Distributed Detection in Sensor Networks with Limited Range Sensors

, 2008
We consider a multi-object detection problem over a sensor network (SNET) with limited range sensors. This problem complements the widely considered decentralized detection problem where all sensors observe the same object. While the necessity for global
Ermis, Erhan B., Saligrama, Venkatesh
core   +1 more source