Results 131 to 140 of about 11,569,212 (291)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Is Distributed Database Evaluation Cloud-Ready?
Symposium on Advances in Databases and Information Systems, 2017 Daniel Seybold, J. Domaschka
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Climates. Habitats. Environments. Database
The Environmentally-Engaged Artistic Practices in South, Southeast Asia and the Pacific Database aspires to provide a comprehensive and rich data source for artists, climate scientists, and policymakers on the artistic practices of artists and ...
Bauer, Ute Meta
core +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Aion: Live Migration for In-Memory Databases with Zero Downtime and Reduced Redundant Data Transfer
Data Science and EngineeringDistributed in-memory databases are widely adopted to achieve low latency and high bandwidth for data-intensive applications. They support scale-out by sharding and distributing data across multiple nodes.
Huijie Cao +7 more
doaj +1 more source
An optimized approach for simultaneous horizontal data fragmentation and allocation in Distributed Database Systems (DDBSs). [PDF]
Heliyon, 2017 Amer AA, Sewisy AA, Elgendy TMA.
europepmc +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Distributed and Parallel Database Systems
, 2014 Chapitre 13The maturation of database management system (DBMS) technology has coincided with significant developments in distributed computing and parallel processing technologies.
Valduriez, Patrick
core +2 more sources
Federated database systems for managing distributed, heterogeneous, and autonomous databases
ACM Computing Surveys, 1990 A. Sheth, J. Larson
semanticscholar +1 more source