Results 121 to 130 of about 1,216,047 (292)

Optimal Solutions for a Class of Impulsive Differential Problems with Feedback Controls and Volterra-Type Distributed Delay: A Topological Approach

open access: yesMathematics
In this paper, the existence of optimal solutions for problems governed by differential equations involving feedback controls is established for when the problem must account for a Volterra-type distributed delay and is subject to the action of impulsive
Paola Rubbioni
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Exploring the Dynamics of Social Media Addiction and Depression Models With Discrete and Distributed Delays

open access: yesIEEE Access
Web-based networking significantly influences daily interactions and user well-being. This study analyzes social media addiction and depression models that incorporate distribution delays to enhance control strategies.
V. Madhusudanan   +4 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Dynamics of a Price Adjustment Model with Distributed Delay

open access: yesMathematics
This paper deals with the stability and occurrence of Hopf bifurcation of a distributed delay differential cobweb model using the chain trick technique.
Luca Guerrini   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

On stability and oscillation of equations with a distributed delay which can be reduced to difference equations

open access: yesElectronic Journal of Differential Equations, 2008
For the equation with a distributed delay $$ x'(t) + ax(t)+ int_0^1 x(s+[t-1])d R(s)=0 $$ we obtain necessary and sufficient conditions of stability, exponential stability and oscillation. These results are applied to some particular cases, such as
Sergey Zhukovskiy, Elena Braverman
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

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