Results 101 to 110 of about 2,641,244 (300)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

pth moment exponential stability of stochastic fuzzy Cohen–Grossberg neural networks with discrete and distributed delays

Nonlinear Analysis, 2017
In this paper, stochastic fuzzy Cohen–Grossberg neural networks with discrete and distributed delays are investigated. By using Lyapunov function and the Ito differential formula, some sufficient conditions for the pth moment exponential stability of ...
Changjin Xu, Peiluan Li
doaj   +1 more source

Global Stability for an Endogenous-Reactivated Tuberculosis Model with Beddington-DeAngelis Incidence, Distributed Delay and Relapse. [PDF]

Qual Theory Dyn Syst, 2023
Sang Y, Zhang L, Song B, Zhang Y.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Mathematical Models of Epidemics with Infection Time

AppliedMath
After an infectious contact, there is a time lapse before the individual actually becomes infected. In this paper, we present different ways of incorporating this incubation or infection time into epidemic mathematical models. For simplicity, we consider
Benito Chen-Charpentier
doaj   +1 more source

Numerical methods and hypoexponential approximations for gamma distributed delay differential equations. [PDF]

IMA J Appl Math, 2022
Cassidy T, Gillich P, Humphries AR, van Dorp CH.   +3 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Viral Infection Model with Diffusion and Distributed Delay: Finite-Dimensional Global Attractor. [PDF]

Qual Theory Dyn Syst, 2023
Rezounenko A.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Medium Entropy Reduction and Instability in Stochastic Systems with Distributed Delay. [PDF]

Entropy (Basel), 2021
Loos SAM, Hermann S, Klapp SHL.
europepmc   +1 more source