Results 91 to 100 of about 248,923 (267)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Backward Continuation of the Solutions of the Cauchy Problem for Linear Fractional System with Deviating Argument

Mathematics
Fractional calculus provides tools to model systems with memory effects; when coupled with delays, they model process histories inspired by two independent sources—the memory of the fractional derivative and the impact conditioned by the delays.
Hristo Kiskinov, Mariyan Milev, Milena Petkova, Andrey Zahariev   +3 more
doaj   +1 more source

Discrete Delay versus Distributed Delay:

Delay equations may incorporate past dependence either through a discrete time lag orthrough a distributed memory kernel. These two formulations represent different mathemat-ical descriptions of hereditary effects. In this work, a compact comparison between discreteand distributed delays is presented.
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Optimal Solutions for a Class of Impulsive Differential Problems with Feedback Controls and Volterra-Type Distributed Delay: A Topological Approach

Mathematics
In this paper, the existence of optimal solutions for problems governed by differential equations involving feedback controls is established for when the problem must account for a Volterra-type distributed delay and is subject to the action of impulsive
Paola Rubbioni
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Exploring the Dynamics of Social Media Addiction and Depression Models With Discrete and Distributed Delays

IEEE Access
Web-based networking significantly influences daily interactions and user well-being. This study analyzes social media addiction and depression models that incorporate distribution delays to enhance control strategies.
V. Madhusudanan, L. Guerrini, B. S. N. Murthy, Nhu-Ngoc Dao, Sungrae Cho   +4 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Dynamics of a Price Adjustment Model with Distributed Delay

Mathematics
This paper deals with the stability and occurrence of Hopf bifurcation of a distributed delay differential cobweb model using the chain trick technique.
Luca Guerrini, Martin Anokye, Albert L. Sackitey, John Amoah-Mensah   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source