Results 81 to 90 of about 1,216,047 (292)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Spatiotemporal Dynamics of a Generalized Viral Infection Model with Distributed Delays and CTL Immune Response

Computation, 2019
In this paper, we propose and investigate a diffusive viral infection model with distributed delays and cytotoxic T lymphocyte (CTL) immune response.
Khalid Hattaf
doaj   +1 more source

Investigation of the complex dynamics and regime control in Pierce diode with the delay feedback

, 2005
In this paper the dynamics of Pierce diode with overcritical current under the influence of delay feedback is investigated. The system without feedback demonstrates complex behaviour including chaotic regimes.
A. E. Hramov, Anfinogentov VG, Granatstein VL, Grassberger P, Hramov AE, I. S. Rempen, Kouomou YC, Pyragas K, Roache PJ, Takens F, Trubetskov DI   +10 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Fundamental Matrix, Measure Resolvent Kernel and Stability Properties of Fractional Linear Delayed System with Discontinuous Initial Conditions

Mathematics
In the present work, a Cauchy (initial) problem for a fractional linear system with distributed delays and Caputo-type derivatives of incommensurate order is considered.
Hristo Kiskinov, Mariyan Milev, Milena Petkova, Andrey Zahariev   +3 more
doaj   +1 more source

Throughput and Delay Scaling in Supportive Two-Tier Networks

, 2011
Consider a wireless network that has two tiers with different priorities: a primary tier vs. a secondary tier, which is an emerging network scenario with the advancement of cognitive radio technologies.
Cui, Shuguang, Gao, Long, Yin, Changchuan, Zhang, Rui   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Statistical multi-moment bifurcations in random delay coupled swarms

, 2012
We study the effects of discrete, randomly distributed time delays on the dynamics of a coupled system of self-propelling particles. Bifurcation analysis on a mean field approximation of the system reveals that the system possesses patterns with certain ...
Brandon Lindley, Ira B. Schwartz, Luis Mier-y-Teran-Romero, N. Leonard, Y.-L. Chuang   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Delayed Energy Demand–Supply Models with Gamma-Distributed Memory Kernels

AppliedMath
The stability of energy demand–supply systems is often affected by delayed feedback caused by regulatory inertia, communication lags, and heterogeneous agent responses.
Carlo Bianca, Luca Guerrini, Stefania Ragni   +2 more
doaj   +1 more source