Results 71 to 80 of about 131,048 (296)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Exponential decay and well-posedness for a one-dimensional porous-elastic system with distributed delay

, 2019
In this paper, we consider a one-dimensional porous-elastic system with distributed delay term acting on the porous equation. Under suitable assumptions on the weight of distributed delay, we establish the well-posedness of the system by using semigroup ...
Houssem Eddine Khochemane (8170263), Amin Guerouah (8170269), Lamine Bouzettouta (8170266)   +2 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Spectral Solution Method for Distributed Delay Stochastic Differential Equations

, 2016
Stochastic delay differential equations naturally arise in models of complex natural phenomena, yet continue to resist efforts to find analytical solutions to them: general solutions are limited to linear systems with additive noise and a single delayed ...
René, Alexandre
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

PHOTONICS TECHNOLOGY AS A WAY FOR UPGRADING KEY TECHNICAL FEATURES OF RADIO-SIGNAL DELAY DEVICES

Российский технологический журнал, 2017
Based on the previous results for our investigations of various retarding materials for super-wide bandwidth long-term delay lines and shortcomings of the available fiberoptic delay links based on binary delay chain where semiconductor optical switches ...
T. N. Bakhvalova, M. E. Belkin, I. V. Gladyshev, S. A. Kudzh, A. S. Sigov   +4 more
doaj   +1 more source

Delay range stability of a class of distributed time delay systems

, 2011
International audienceThis paper is dedicated to the stability analysis of a class of uncertain distributed delay systems, the kernel of which can be modeled as a polynomial function of the delay. The results are constructed by rewriting the system as an
Gouaisbaut, Frédéric, F. Gouaisbaut, Ariba, Yassine, Y. Ariba   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Distributed delay differential model of a multimode semiconductor laser

, 2017
Mode-locking is a very efficient technique to generate short optical pulses with high repetition rates used in many applications. A conventional approach to model semiconductor mode-locked lasers is based on the use of the so-called traveling wave ...
Pimenov, Alexander, Vladimirov, Andrei G., Slepneva, Svetlana, Huyet, Guillaume   +3 more
core   +1 more source