Results 71 to 80 of about 273,919 (256)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Research on Speed Planning and Energy Management Strategy for Distributed-Drive Electric Vehicles Based on Deep Deterministic Policy Gradient Algorithm

Actuators
Fully leveraging the four-wheel independent drive characteristics of distributed-drive electric vehicles has become essential for enhancing their driving range.
Ning Li, Yong Lin, Zhongyuan Huang, Yihao Hong, Xiaobin Ning   +4 more
doaj   +1 more source

Multi-Objective Optimization Control of Distributed Electric Drive Vehicles Based on Optimal Torque Distribution

IEEE Access, 2019
To improve the total efficiency of the drive system and the driving safety of distributed electric drive vehicles, this paper proposes a multi-objective optimization method based on torque allocation optimization. First, in the vehicle nonlinear dynamics
Juhua Huang, Yingkang Liu, Mingchun Liu, Ming Cao, Qihao Yan   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Analysis of Wheel Hub Motor Drive Application in Electric Vehicles

MATEC Web of Conferences, 2017
Based on the comparative analysis of the performance characteristics of centralized and distributed drive electric vehicles, we found that the wheel hub motor drive mode of the electric vehicles with distributed drive have compact structure, high ...
Sun Yuechao, Li Man, Liao Cong
doaj   +1 more source

Distribution of inspiratory drive to the external intercostal muscles in humans

The Journal of Physiology, 2003
The external intercostal muscles in humans show marked regional differences in respiratory effect, and this implies that their action on the lung during breathing is primarily determined by the spatial distribution of neural drive among them. To assess this distribution, monopolar electrodes were implanted under ultrasound guidance in different muscle ...
De Troyer, André, Gorman, Robert B., Gandevia, Simon C.   +2 more
openaire   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dynamical Model And Ride Comfort Simulation Analysis Of Distributed Drive Electric Vehicle

MATEC Web of Conferences, 2018
This paper analyzes the ride comfort of distributed electric vehicle, simplifies a distributed electric vehicle to a fifteen degree of freedom model, and deduces the vibration differential equation by Newton 's second theorem.
Xiao Wenwen, Zhang Huanhuan
doaj   +1 more source