Results 61 to 70 of about 299,834 (255)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Comprehensive Investigations on 1053 nm Random Distributed Feedback Fiber Laser

IEEE Photonics Journal, 2017
We design a 1053 nm Yb3+-doped random fiber laser (YRFL) based on the combination of Yb3+ -doped fiber (YDF) and single mode fiber (SMF), in which the YDF provides active gain, while SMF offers random distributed feedback.
Mengqiu Fan, Zhaoyu Zon, Xiaocheng Tian, Dangpeng Xu, Dandan Zhou, Rui Zhang, Na Zhu, Lianghua Xie, Hongxun Li, Jingqin Su, Qihua Zhu   +10 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Fiber optic computing using distributed feedback

Communications Physics
The widespread adoption of machine learning and other matrix intensive computing algorithms has renewed interest in analog optical computing, which has the potential to perform large-scale matrix multiplications with superior energy scaling and lower ...
Brandon Redding, Joseph B. Murray, Joseph D. Hart, Zheyuan Zhu, Shuo S. Pang, Raktim Sarma   +5 more
doaj   +1 more source

Tunable Erbium-Doped Fiber Laser Based on Random Distributed Feedback

IEEE Photonics Journal, 2014
A tunable erbium-doped fiber (EDF) laser based on random distributed feedback through backward Rayleigh scattering in a 20-km-long single-mode fiber and a tunable fiber Fabry-Perot interferometer filter is demonstrated.
Lulu Wang, Xinyong Dong, Perry Ping Shum, Haibin Su   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Symmetric Step-Apodized Distributed Feedback Fiber Laser With Improved Efficiency

IEEE Photonics Journal, 2019
We propose and demonstrate a symmetric step-apodized distributed feedback (DFB) fiber laser, which has an improved efficiency and a narrow linewidth. This special DFB laser cavity is based on a unique symmetric step-apodized π-phase-shifted fiber ...
Kuikui Guo, Jun He, Kaiming Yang, Zhe Zhang, Xizhen Xu, Bin Du, Gaixia Xu, Yiping Wang   +7 more
doaj   +1 more source